{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T10:10:29Z","timestamp":1770718229129,"version":"3.49.0"},"reference-count":41,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:00:00Z","timestamp":1759449600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:00:00Z","timestamp":1759449600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Vasc Res"],"abstract":"Introduction: In our study, the possible role of the calcium-sensing receptor (CaSR) pathway in L-cysteine-\/hydrogen sulfide (H<sub>2<\/sub>S)-induced vasorelaxations was investigated in isolated mouse thoracic aorta tissue. Methods: For this purpose, vasorelaxations to L-cysteine (H<sub>2<\/sub>S substrate; 1 \u00b5<sc>m<\/sc>\u201310 m<sc>m<\/sc>) and calindol (CaSR agonist; 0.3\u201310 \u03bc<sc>m<\/sc>) were measured in endothelial-intact and -denuded thoracic aorta segments contracted with phenylephrine (5 \u03bc<sc>m<\/sc>). Also, the effects of propargylglycine (PAG) and Calhex-231, cystathionine-gamma-lyase (CSE) and CaSR inhibitor, respectively, on L-cysteine- and calindol-induced vasorelaxations were investigated in thoracic aorta segments. In addition, the effects of L-cysteine, calindol, and endothelium on H<sub>2<\/sub>S generation in mouse aorta segments were investigated. Results: L-cysteine- and calindol-induced vasorelaxations were reduced in the presence of PAG and Calhex-231. Furthermore, in endothelium-denuded tissues, the vasorelaxations to calindol and L-cysteine were reduced compared to endothelium-intact tissues. Also, calindol increased basal H<sub>2<\/sub>S generation, and PAG and Calhex-231 reduced the increase in H<sub>2<\/sub>S production stimulated with calindol. Calhex-231 reduced the increase in H<sub>2<\/sub>S production in the presence of L-cysteine. Also, H<sub>2<\/sub>S production decreased in endothelium-denuded tissues. Conclusion: Endogenous H<sub>2<\/sub>S generated by CSE produces endothelium-dependent relaxation by activating CaSR in mouse thoracic aorta tissue.<\/jats:p>","DOI":"10.1159\/000548774","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T16:01:08Z","timestamp":1759507268000},"page":"53-64","source":"Crossref","is-referenced-by-count":0,"title":["Evidence in Favor of Calcium-Sensing Receptor in L-Cysteine-Mediated Vasorelaxation of Mouse Thoracic 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