{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T17:05:14Z","timestamp":1763571914552,"version":"3.45.0"},"reference-count":33,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"abstract":"<jats:p>Introduction: Hypoxic-ischaemic encephalopathy (HIE) due to perinatal asphyxia remains a significant cause of neonatal morbidity and mortality. Despite therapeutic hypothermia (TH), a considerable proportion of survivors experience a wide range of deficits, including auditory impairment (AI), which needs deeper knowledge. This review aimed to describe AI outcomes in infants with HIE. Methods: A systematic literature review was performed using standard methods outlined by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol. A qualitative synthesis of all the included studies and a meta-analysis with seven eligible studies were conducted. Results: In the sixteen studies comprised, a mean incidence of 4.54% of AI occurred among participants meeting the inclusion criteria. In the meta-analysis, in subgroup A (healthy newborns vs. newborns with HIE), an OR = 10.74 with a 95% CI 2.02\u201357.16 and a p value of 0.010 was observed, indicating tenfold higher odds of AI in HIE newborns; subgroup B (newborns with HIE who received standard care vs. those who underwent TH) exhibited an OR = 0.77 with a 95% CI 0.35\u20131.68 and a p value of 0.510, demonstrating that newborns who received TH had a 0.77-fold lower odds of developing AI. Conclusion: This review highlights HIE as a risk factor for AI and the possibility of TH being a protective factor. However, the variations in participant characteristics, HIE criteria, and methods of hearing assessment contribute to significant variability between studies, identifying the need for a standard evaluation of auditory outcomes in this setting, extended over the long term.<\/jats:p>","DOI":"10.1159\/000548779","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:01:22Z","timestamp":1760025682000},"page":"1-9","source":"Crossref","is-referenced-by-count":0,"title":["Auditory Impairment in Infants with Neonatal Hypoxic-Ischaemic Encephalopathy: A Systematic Review and Meta-Analysis"],"prefix":"10.1159","author":[{"given":"Carla","family":"Fernandes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7413-4528","authenticated-orcid":false,"given":"Filipa Andrade","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e1rbara","family":"Oliveiros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla Regina","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000524751"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-12091-x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.55730\/1300-0144.5375"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmaa073"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcps050929"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/apa.13392"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003311.pub3"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2478\/prilozi-2022-0013"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3109\/14992027.2012.673237"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1044\/jslhr.4101.83"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2009.02.378"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2019.109691"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2022-324418"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0900854"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)17946-X"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2441"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2009.11.008"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.06.012"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2014.01.012"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.04.041"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.7218"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2021.109724"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11112056"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-022-04778-0"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2023.113402"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1089\/ther.2020.0043"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c363"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2018.10.002"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-023-05321-5"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1083842"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2010.01.008"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1136\/bmjpo-2023-002487"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000548779","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T17:00:58Z","timestamp":1763571658000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000548779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,9]]},"references-count":33,"URL":"https:\/\/doi.org\/10.1159\/000548779","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.30318730","asserted-by":"subject"}]},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"type":"print","value":"1661-7800"},{"type":"electronic","value":"1661-7819"}],"subject":[],"published":{"date-parts":[[2025,10,9]]}}}