{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:52:09Z","timestamp":1788778329617,"version":"build-2803163510"},"reference-count":22,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"abstract":"<jats:p>Introduction: This study aimed to examine the effects of sodium-glucose cotransporter 2 inhibitors (SGLT2i) on cardiac structure and cardiorenal function in older adults with hypertension and pre-heart failure. Methods: A total of 88 patients with hypertension and pre-heart failure who received care at the hospital between August 2022 and August 2024 were enrolled and randomly assigned to either a dapagliflozin group or a conventional treatment group. Changes in N-terminal pro-brain natriuretic peptide (NT-proBNP), troponin I (TnI), estimated glomerular filtration rate (eGFR), interleukin-6 (IL-6), high-sensitivity C-reactive protein (hsCRP), procalcitonin (PCT), left ventricular end-diastolic volume (LVEDV), ejection fraction, left atrial volume index (LAVI), and left ventricular mass index were assessed and compared between the two groups before and after 3 months of treatment. Results: No significant differences were observed in NT-proBNP, TnI, eGFR, IL-6, and hsCRP levels between the two groups before treatment. Additionally, there were no differences in PCT, TnI, and LVEDV between the groups at 3 months post-treatment. However, IL-6, hsCRP, and eGFR levels were significantly lower in the dapagliflozin group compared to the conventional treatment group at 3 months post-treatment (p &lt; 0.05). Additionally, the LAVI was significantly lower in the dapagliflozin group relative to the conventional treatment group, with the difference being statistically significant (p &lt; 0.05). Conclusion: These findings indicate that SGLT2i therapy may contribute to early myocardial remodeling and improvement in cardiorenal function in older adults with hypertension and pre-heart failure. Furthermore, prolonged SGLT2i administration appears to exert anti-inflammatory effects.<\/jats:p>","DOI":"10.1159\/000548905","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T17:01:06Z","timestamp":1762534866000},"page":"1-8","source":"Crossref","is-referenced-by-count":1,"title":["The Effect of Sodium-Dependent Glucose Transporter 2 Inhibitors on Cardiac Structural and Functional Indicators and Biochemical Markers in Older Adults with Hypertension and Pre-Heart Failure"],"prefix":"10.1159","author":[{"given":"Hui-Juan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei-Guang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao-Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie-Yun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2025,11,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn112148-20231101-00405"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.025519"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1629"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.16483"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.122.19373"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001063"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-018-4670-7"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m4573"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2021.154937"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/CNQ.0000000000000401"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.028441"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2020.6566"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2022.03.019"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2023.0065"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.7326\/M21-4284"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.01.056"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-021-01312-8"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2020.07.042"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.122.062769"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.021887"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12505"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3967\/bes2024.162"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000548905","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T17:05:10Z","timestamp":1764608710000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000548905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,7]]},"references-count":22,"URL":"https:\/\/doi.org\/10.1159\/000548905","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"value":"0008-6312","type":"print"},{"value":"1421-9751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,7]]}}}