{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T21:21:37Z","timestamp":1770758497228,"version":"3.50.0"},"reference-count":28,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"abstract":"<jats:p>Introduction: Graves\u2019 disease is associated with cardiovascular alterations. Data on the left ventricular (LV) function and left atrial (LA) mechanics in Graves\u2019 disease remain limited. This study investigated the relationship between disease duration and myocardial deformation parameters, including LA strain and LV global longitudinal strain (LV-GLS). Methods: In this cross-sectional study, 90 patients with Graves\u2019 disease underwent comprehensive echocardiographic assessment. Disease duration was classified as short (\u22642 years) or long (&gt;2 years) based on receiver operating characteristic analysis. LA reservoir strain (LASr), conduit strain (LAScd), contractile strain (LASct), and LV-GLS were measured. In addition, strain parameters were compared between patients according to thyroid status (euthyroid vs. hyperthyroid). Results: Patients with longer disease duration showed significantly reduced LASr (36.9 \u00b1 12.0% vs. 46.3 \u00b1 11.0%, p = 0.001), LAScd (\u221220.2 \u00b1 9.3% vs. \u221226.3 \u00b1 9.4%, p = 0.007), LASct (\u221217.0 \u00b1 6.4% vs. \u221219.9 \u00b1 5.9%, p = 0.045), and absolute LV-GLS (20.8% [18.4%\u201324.9%] vs. 24.3% [21.7%\u201327.4%], p = 0.007). Disease duration correlated negatively with LASr (r = \u22120.340, p &lt; 0.001) and absolute LV-GLS (r = \u22120.311, p = 0.003). Multivariate analysis identified LASr (OR = 0.947, p = 0.017) and LV-GLS (OR = 0.838, p = 0.020) as independent predictors of prolonged disease duration. In euthyroid patients with longer disease duration, strain parameters were significantly lower than in hyperthyroid patients with shorter duration. Conclusion: Longer Graves\u2019 disease duration is associated with progressive subclinical impairment of atrial and ventricular mechanics, with strain abnormalities evident even in euthyroid patients. These findings highlight the cumulative impact of disease chronicity and support the use of speckle-tracking echocardiography for early detection of myocardial dysfunction and closer cardiovascular monitoring in this population.<\/jats:p>","DOI":"10.1159\/000548952","type":"journal-article","created":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T16:00:58Z","timestamp":1760976058000},"page":"130-140","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Disease Duration on Left Atrial Function in Patients with Graves\u2019 Disease"],"prefix":"10.1159","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3935-0222","authenticated-orcid":false,"given":"Selda","family":"Murat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9688-110X","authenticated-orcid":false,"given":"Fatih 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