{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:08:45Z","timestamp":1790644125806,"version":"4.1.0"},"reference-count":71,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychother Psychosom"],"abstract":"<jats:p>&lt;p&gt;Introduction: Obsessive-compulsive disorder (OCD) is a chronic condition where many patients remain symptomatic despite first-line treatments such as cognitive behavioural therapy and selective serotonin reuptake inhibitors. This randomised controlled trial evaluated mindfulness-based cognitive therapy (MBCT) efficacy as an augmentation strategy and its impact on brain functional connectivity. Methods: Sixty-eight participants with moderately symptomatic OCD were randomised into MBCT or treatment as usual (TAU). Clinical outcomes were evaluated using the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) and the Obsessive-Compulsive Inventory, alongside other relevant secondary outcomes. Data were analysed using repeated-measures ANOVA to assess time * group effects. Neuroimaging functional measures (resting-state network connectivity) were collected before and after the intervention and analysed using independent component analysis. Results: Primary outcome: MBCT significantly reduced OCD symptoms compared to TAU (31.73% vs. 8.07% Y-BOCS reduction). Secondary outcomes: the MBCT group also experienced reductions in depressive symptoms, rumination, perceived stress, and quality of life. No significant post-treatment changes were observed in resting-state connectivity. However, baseline connectivity demonstrated significant predictive value, with lower connectivity in preselected networks of interest, including the fronto-striatal, salience, and default mode networks, associated with greater reductions in Y-BOCS scores. Conclusion: MBCT is an effective strategy for individuals with moderately symptomatic OCD who continue to experience symptoms despite prior gold-standard treatments. While no post-treatment changes in brain functional connectivity were observed, baseline connectivity patterns predicted symptom reduction, suggesting a neural basis for MBCT response. &lt;\/p&gt;<\/jats:p>","DOI":"10.1159\/000548961","type":"journal-article","created":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T16:01:08Z","timestamp":1760976068000},"page":"318-334","source":"Crossref","is-referenced-by-count":2,"title":["Clinical and Neuroimaging Effects of Mindfulness-Based Cognitive Therapy for Symptomatic Obsessive-Compulsive Disorder Patients after First-Line Treatments: A Randomised Controlled Trial"],"prefix":"10.1159","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5793-9906","authenticated-orcid":false,"given":"Maria","family":"Serra-Blasco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neus","family":"Miquel-Giner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Vicent-Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Porta-Caster\u00e0s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Mart\u00ednez-Zalaca\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0675-9483","authenticated-orcid":false,"given":"Marta","family":"Cano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edctor","family":"De la Pe\u00f1a-Arteaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorea","family":"Mar-Barrutia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Alemany-Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carles","family":"Soriano-Mas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"L\u00f3pez-Sol\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica R.","family":"Andrews-Hanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria J.","family":"Portella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquim","family":"Soler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narc\u00eds","family":"Cardoner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pino","family":"Alonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"L\u00f3pez-Sol\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2025,10,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425787"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2021.152223"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2015.06.003"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.9758\/cpn.23.1075"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.2200"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2019.102135"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2020.112821"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-12-185"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/clipsy.bpg016"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1177\/1745691611419671"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocrd.2022.100712"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/cpp.2076"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-018-0957-4"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.12.082"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.661807"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2018.04.007"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291721001744"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.703701"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/jclp.23240"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijchp.2022.100321"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1037\/cps0000132"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2020.20111601"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3469"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2020_203"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.09.030186.002041"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2003.10.003"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2017.07.041"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2013.09.004"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2013.0475"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2009.152"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-023-02077-0"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2022.104574"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1007\/s12144-023-04312-x"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1007\/s12671-022-01919-2"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-17325-6"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-15195-6"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1007\/s12671-025-02549-0"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1038\/S41398-023-02642-9"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016\/J.RPSM.2022.11.002"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.09.015"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2014.03.012"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocrd.2016.02.001"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2010.06.001"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2019.01.092"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1080\/16506073.2018.1556330"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0000000000000938"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1007\/s12671-020-01582-5"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.2196\/23491"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1177\/2470547018758043"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1002\/cpp.2392"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2009.04.005"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2016.07.001"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2020.01.033"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.210084"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-023-01594-x"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17593-7"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2015.05.004"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2020.110037"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.1063116"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2024.152462"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2024.02.011"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24972"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1996.01830070041008"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab483"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2016.10.011"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291717002288"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.160215"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2020-324478"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2012.00346"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.03.021"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2022.110563"}],"container-title":["Psychotherapy and Psychosomatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000548961","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:01:04Z","timestamp":1784304064000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000548961"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,20]]},"references-count":71,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,7,17]]},"published-print":{"date-parts":[[2026,8,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000548961","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.30385021","asserted-by":"subject"}]},"ISSN":["0033-3190","1423-0348"],"issn-type":[{"value":"0033-3190","type":"print"},{"value":"1423-0348","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,20]]}}}