{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T17:03:45Z","timestamp":1775149425664,"version":"3.50.1"},"reference-count":14,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"abstract":"<jats:p>&lt;p&gt;Background: Curcumin has emerged as promising candidate for therapeutic modulation of neurodegenerative disorders by acting on \u03b17-nicotinic acetylcholine receptor (\u03b17-nAChR). Objective: This study aimed to evaluate the potential of curcumin metabolites and derivatives as positive allosteric modulators (PAMs) of \u03b17-nAChR. Materials and Methods: Functional properties of \u03b17-nAChR were assessed using two-electrode voltage clamp techniques in Xenopus oocytes, and molecular docking studies were employed to identify high-affinity binding sites. Results: The findings reveal that curcumin metabolites and derivatives also potentiate \u03b17-nAChR and interact with a common transmembrane domain binding site on \u03b17-nAChR, demonstrating potent modulatory effects. Notably, these derivatives exhibit superior binding energies compared to the established PAM PNU-120596. Conclusion: The study underscores the therapeutic potential of curcumin metabolites and derivatives as receptor-specific natural agents for managing neurodegenerative and inflammatory diseases. &lt;\/p&gt;<\/jats:p>","DOI":"10.1159\/000548995","type":"journal-article","created":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T16:01:11Z","timestamp":1760976071000},"page":"190-195","source":"Crossref","is-referenced-by-count":0,"title":["Curcumin Derivatives as Allosteric Modulator of \u03b17-nAChR: Functional and Molecular Docking Insights"],"prefix":"10.1159","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4429-1749","authenticated-orcid":false,"given":"Eslam","family":"ElNebrisi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad A.","family":"Ghattas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noor","family":"Atatreh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Hasan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Oz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,10,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2021.11.006"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.01021"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.117.245068"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2017.12.010"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22020973"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14061296"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/s0003-9861(02)00279-5"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804372105"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22147251"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21197329"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2015.06.018"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.01274"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.172411"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-021-00509-6"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000548995","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T16:02:59Z","timestamp":1775145779000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000548995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,20]]},"references-count":14,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,4,2]]},"published-print":{"date-parts":[[2026,4,7]]}},"URL":"https:\/\/doi.org\/10.1159\/000548995","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.30391168","asserted-by":"subject"}]},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"value":"1011-7571","type":"print"},{"value":"1423-0151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,20]]}}}