{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T16:15:00Z","timestamp":1778256900249,"version":"3.51.4"},"reference-count":26,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"abstract":"<jats:p>Introduction: This study aimed to assess whether levels of interleukin 6 (IL-6) in amniotic fluid (AF) can predict perinatal complications following fetal laser surgery in monochorionic twins with twin-to-twin transfusion syndrome (TTTS). Methods: We conducted a retrospective cohort study at the Fetal Medicine Center from 2013 to 2024, analyzing AF samples from 152 monochorionic twin pregnancies prior to surgery. Cutoff levels for IL-6 were set at 400 ng\/L and 2,000 ng\/L based on a 10% false-positive and -negative rate. Results: Among the 152 women who underwent laser surgery, significant associations were found between AF IL-6 levels and pregnancy duration in TTTS cases (p = 0.005); in cases complicated by selective growth restriction, no significant association was found (p = 0.584). Overall, 112 TTTS pregnancies were categorized into 3 groups according to IL-6 levels. The overall prevalence of short surgery-delivery interval (&lt;14 days) was 11.6% (13\/112), 1.9% in the low-risk group, and 21.4% in the high-risk group (OR 13.9, p = 0.028). The risk of preterm birth (\u226428 weeks) was also higher in the high-risk group (50% vs. 9.6%, OR 9.4, p = 0.002), and adverse neonatal outcomes were more prevalent (63.6% vs. 20%, OR 7.0, p = 0.007). Conclusion: AF IL-6 levels are a reliable marker for predicting adverse perinatal outcomes after fetal laser surgery, showing a high negative predictive value.<\/jats:p>","DOI":"10.1159\/000549016","type":"journal-article","created":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T16:01:12Z","timestamp":1760976072000},"page":"146-156","source":"Crossref","is-referenced-by-count":0,"title":["Preoperative Amniotic Fluid Interleukin-6 Levels as Predictors of Adverse Perinatal Outcomes following Fetal Laser Surgery for Monochorionic Twin Complications"],"prefix":"10.1159","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7092-387X","authenticated-orcid":false,"given":"Petra","family":"Hanulikova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3416-8106","authenticated-orcid":false,"given":"Lubomir","family":"Haslik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7372-3953","authenticated-orcid":false,"given":"Ladislav","family":"Krofta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Brandejsova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Regendova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Vankova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matus","family":"Halaj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,10,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines13010118"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.61014"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000358516"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9072085"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0000000000000247"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.21037\/tp-20-264"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7200292"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15821"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/uog.4046"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/uog.21882"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000004479"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.14524"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.03.069"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2009.10.027"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.960834"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8070969"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2017.1404983"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/uog.19078"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159\/000374109"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.11.031"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23519"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.15419\/bmrat.v11i2.868"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20228"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14696"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5246"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4031"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000549016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T16:01:17Z","timestamp":1778256077000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000549016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,20]]},"references-count":26,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,5,8]]},"published-print":{"date-parts":[[2026,5,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000549016","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"value":"1015-3837","type":"print"},{"value":"1421-9964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,20]]}}}