{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T07:04:35Z","timestamp":1777100675112,"version":"3.51.4"},"reference-count":35,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron"],"abstract":"<jats:p>Introduction: Pulmonary hypertension and right ventricular (RV) dysfunction are associated with an increase in mortality and worse prognosis in patients with end-stage kidney disease (ESKD), but pathophysiologic mechanisms underlying the progression of RV dysfunction remain incompletely understood. The present study aimed to understand right ventricular to pulmonary artery (RV-PA) coupling, which is an early indicator of transition to RV dysfunction, to better characterize adaptive RV response to increased afterload in ESKD patients and changes in RV-PA coupling following renal transplantation. Methods: One hundred eleven patients with ESKD, including 49 patients scheduled for renal transplantation, underwent a detailed echocardiographic examination and measurement of tricuspid annular plane excursion to pulmonary artery systolic pressure (TAPSE\/PASP) ratio, and a repeat examination was performed 6 months after the baseline examination. Results: Patients with ESKD had significantly lower TAPSE\/PASP ratio at baseline (1.02 [0.71\u20131.63] vs. 1.29 [1.09\u20131.96], p &lt; 0.001). In 40 patients that underwent transplantation, TAPSE\/PASP ratio increased significantly from (0.97 [0.72\u20131.42] to 1.30 [1.01\u20131.82], p = 0.03), while in 27 patients remained on dialysis, there was a nonsignificant reduction in TAPSE\/PASP ratio (1.21 [0.71\u20131.62] vs. 0.84 [0.61\u20131.38], p = 0.44). The change in TAPSE\/PASP ratio correlated significantly with the change in pulmonary vascular resistance (OR: 0.61, 95% CI: 0.51\u20130.72, p &lt; 0.001) and left ventricular mass index (OR: 0.97, 95% CI: 0.96\u20130.99, p = 0.001) after adjustment. Conclusions: Patients with ESKD had abnormal RV-PA coupling, as indicated by a reduced TAPSE\/PASP ratio, which normalizes 6 months after renal transplantation.<\/jats:p>","DOI":"10.1159\/000549077","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:01:38Z","timestamp":1761843698000},"page":"87-98","source":"Crossref","is-referenced-by-count":1,"title":["Abnormal Right Ventricular to Pulmonary Artery Coupling in Patients with End-Stage Kidney Disease and Normalization after Renal Transplantation: An Observational Study"],"prefix":"10.1159","volume":"150","author":[{"given":"Rengin","family":"\u00c7etin G\u00fcven\u00e7","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6738-266X","authenticated-orcid":false,"given":"Tolga Sinan","family":"G\u00fcven\u00e7","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ezgi 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