{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T12:15:32Z","timestamp":1784895332996,"version":"3.55.0"},"reference-count":16,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Blood Purif"],"abstract":"<jats:p>&lt;p&gt;Introduction: The selective cytopheretic device (SCD) is a cell-directed extracorporeal therapy approved for use in children with acute kidney injury (AKI) receiving continuous renal replacement therapy (CRRT) with sepsis\/sepsis-like conditions. We compared outcomes for children treated with SCD to a contemporary cohort of children treated with CRRT alone. Methods: Secondary analysis and comparison of patients \u226422 years old and \u226510 kg from a multicenter registry of patients receiving CRRT for AKI and\/or fluid overload (WE-ROCK; 2015\u20132021) to patients from two multicenter, prospective, interventional studies of children with AKI and multiple organ dysfunction (MODS) receiving SCD (SCD-PED-01\/SCD-PED-02; 2016\u20132022). Results: Eighteen patients in the SCD cohort were compared to 178 in the CRRT cohort. There were no differences between cohorts at CRRT \u00b1 SCD initiation. SCD patients had shorter CRRT duration (6 [3, 11] vs. 10 [5, 18] days, p = 0.013) and shorter ICU length of stay (LOS) in survivors (16 [11, 25] vs. 27 [16, 46] days, p = 0.012). Survival to ICU discharge or day 60 was 94% in the SCD cohort vs. 74% in the CRRT cohort (p = 0.079). A Bayesian analysis demonstrated a &gt;99% probability of improved survival with SCD. A sub-analysis in septic patients demonstrated greater survival (100% vs. 69%, p = 0.032), shorter CRRT duration (5 [3, 7] vs. 11 [6, 17] days, p = 0.006) and reduced ICU LOS in survivors (21 [10, 25] vs. 27 [16, 45] days, p = 0.027) in SCD-treated patients. Conclusions: The addition of SCD therapy in children with AKI and MODS receiving CRRT may be beneficial, though larger prospective studies are needed. &lt;\/p&gt;<\/jats:p>","DOI":"10.1159\/000549111","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:00:56Z","timestamp":1761235256000},"page":"107-113","source":"Crossref","is-referenced-by-count":2,"title":["Use of the Selective Cytopheretic Device with Continuous Renal Replacement Therapy in Children: A Comparison of Contemporary Cohorts"],"prefix":"10.1159","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4473-8376","authenticated-orcid":false,"given":"Natalja L.","family":"Stanski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JangDong","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Jenkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelli A.","family":"Krallman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8473-0307","authenticated-orcid":false,"given":"Shina","family":"Menon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. David","family":"Humes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Askenazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajit K.","family":"Basu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5123-6713","authenticated-orcid":false,"given":"Ayse","family":"Akcan-Arikan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3711-8785","authenticated-orcid":false,"given":"Stuart L.","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7427-670X","authenticated-orcid":false,"given":"Katja M.","family":"Gist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the WE-ROCK Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2025,10,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2020.12.010"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199605000-00004"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/sdi.12032"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0132482"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/CCE.0000000000000694"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2017.06.131"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1611391"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2023.12.017"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.0243"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.xkme.2024.100792"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000003332"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-024-06438-x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000006405"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/CCE.0000000000000995"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018584"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2023.05.026"}],"container-title":["Blood Purification"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000549111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T17:02:18Z","timestamp":1770051738000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000549111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,23]]},"references-count":16,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,2,2]]},"published-print":{"date-parts":[[2026,2,4]]}},"URL":"https:\/\/doi.org\/10.1159\/000549111","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.30405298","asserted-by":"subject"}]},"ISSN":["0253-5068","1421-9735"],"issn-type":[{"value":"0253-5068","type":"print"},{"value":"1421-9735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,23]]}}}