{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T12:50:31Z","timestamp":1765371031275,"version":"3.46.0"},"reference-count":19,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sex Dev"],"abstract":"<jats:p>&lt;p&gt;Introduction: Although maternal microchimerism has been implicated in various disorders in children, its association with the risk of 46,XY disorders of sex development remains unknown. Methods: We studied 22 boys with hypospadias using highly sensitive quantitative PCR assays. In seven cases with additional anomalies, microarray-based comparative genomic hybridization and whole-exome sequencing confirmed the lack of apparent pathogenic variants. Results: Maternal microchimeric cells were detected in 2 patients (1.9 and 32.0 cells per 106 total cells). The results were comparable to our reference data. Conclusion: This study argues against the significant role of maternal microchimerism in the risk of hypospadias. &lt;\/p&gt;<\/jats:p>","DOI":"10.1159\/000549218","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T17:02:23Z","timestamp":1761757343000},"page":"51-55","source":"Crossref","is-referenced-by-count":0,"title":["Maternal Microchimerism Is Uncommon in Patients with Hypospadias"],"prefix":"10.1159","author":[{"given":"Yuki","family":"Muranishi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Katoh-Fukui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Kon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiko","family":"Koga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Tamaoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1511-4820","authenticated-orcid":false,"given":"Atsushi","family":"Hattori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuo","family":"Shinohara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashige","family":"Abe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9971-4035","authenticated-orcid":false,"given":"Maki","family":"Fukami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,10,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diff.2012.06.003"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2015.12.002"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1055\/s-0044-1787670"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu364"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2012.03.002"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.0636a.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0606169104"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0568"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/dme.14221"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003388"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000510532"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.06.017"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deae057"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-020-01149-x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159\/000489451"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.09.047"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-015-9731-y"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0615-4"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2023.104124"}],"container-title":["Sexual Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000549218","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T09:19:02Z","timestamp":1765358342000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000549218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,27]]},"references-count":19,"URL":"https:\/\/doi.org\/10.1159\/000549218","archive":["Portico"],"relation":{},"ISSN":["1661-5425","1661-5433"],"issn-type":[{"type":"print","value":"1661-5425"},{"type":"electronic","value":"1661-5433"}],"subject":[],"published":{"date-parts":[[2025,10,27]]}}}