{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T18:01:11Z","timestamp":1772733671371,"version":"3.50.1"},"reference-count":49,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ocul Oncol Pathol"],"abstract":"<jats:p>&lt;p&gt;Background: Ocular malignancies are rare compared to tumors affecting other organs. The treatment options for these cancers remain limited, mostly restricted to nonspecific chemotherapeutic drugs, radiation therapy, and surgery. Because of their infrequency, these tumors have received minimal attention in the broader field of cancer biology. In recent years, efforts have focused on elucidating the role of molecular pathways driving these ocular tumors with the goal of developing targeted therapies. Summary: Aurora kinases (AURKs), specifically aurora kinase A (AURKA) and aurora kinase B (AURKB) that play pivotal roles in cell division, have garnered prominence due to their role in tumor progression. Although AURKs have not been extensively explored as therapeutic targets in ocular cancers, a few reports on retinoblastoma (RB) and uveal melanoma (UM) suggest their therapeutic potential. We discuss the functions of aurora kinases in normal and cancer cells, their dysregulation in ocular malignancies, including RB and UM, in this review. We conclude the review with a perspective on how recent therapeutic approaches could improve the efficacy of aurora kinase inhibition. Key Messages: AURKA and AURKB are crucial regulators of tumor progression in RB and UM. Aurora kinase inhibition can be explored as a novel therapeutic strategy. &lt;\/p&gt;<\/jats:p>","DOI":"10.1159\/000549336","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T17:01:13Z","timestamp":1761930073000},"page":"44-52","source":"Crossref","is-referenced-by-count":0,"title":["Aurora Kinases in Ocular Malignancies: Functional Significance and Potential Implications"],"prefix":"10.1159","volume":"12","author":[{"given":"Saswati S.","family":"Lenka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naheed 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