{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:44:05Z","timestamp":1777337045711,"version":"3.51.4"},"reference-count":18,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologica"],"abstract":"<jats:p>Introduction: The aim of the study was to compare clinical findings, OCT characteristics, and postoperative outcomes in eyes with epiretinal membrane (ERM) with and without associated epiretinal proliferation (EP). Methods: Eyes with ERM with or without associated EP were analyzed for clinical findings and OCT characteristics. The primary outcomes measured were changes in best-corrected visual acuity (BCVA) and OCT features from baseline to the final follow-up visit. Patients with ERM were categorized into two groups based on the presence or absence of EP. Surgical outcomes were also evaluated. Results: Significant changes were reached in each group, particularly for BCVA (p &lt; 0.001 for the ERM group, p = 0.010 for the EP-ERM group). Compared with ERM eyes, EP-ERM had a lower BCVA recovery at 6 months after surgery (p = 0.009). EP-ERM patients demonstrated more frequent microcystic macular edema (MME) (73.3% vs. 37.1%, p = 0.008) and increased central retinal thickness (CRT) (p &lt; 0.001) at 6 months after surgery. No statistically significant differences in terms of external limiting membrane and ellipsoid zone defects were registered at 6 months (p = 0.234, p = 0.446, respectively). Conclusion: EP-ERM showed poorer post-surgical BCVA compared with ERM alone. EP-ERM had a greater chance of MME at 6 months after surgery, with higher CRT. These findings highlight the need for deeper assessment of ERM characteristics to accurately predict surgical outcomes.<\/jats:p>","DOI":"10.1159\/000549449","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T17:01:13Z","timestamp":1762448473000},"page":"8-16","source":"Crossref","is-referenced-by-count":3,"title":["Surgical Outcomes of Epiretinal Membranes with and without Epiretinal Proliferation: A Comparative Study"],"prefix":"10.1159","volume":"249","author":[{"given":"Alberto","family":"Quarta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Toto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Gironi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5856-6686","authenticated-orcid":false,"given":"Maria Ludovica","family":"Ruggeri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agbeanda Omer","family":"Aharrh-Gnama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annamaria","family":"Porreca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucio","family":"Zeppa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Gabriele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrica","family":"Greco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Di Nicola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodolfo","family":"Mastropasqua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,11,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001069"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000163"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2019.03.022"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2017-311810"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/s40942-020-00233-0"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2016.12.006"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2017.06.023"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000004429"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-025-06815-8"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2015.05.010"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-8227"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-023-06366-w"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000003537"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000002266"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136\/bjo-2024-326442"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001591"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000004261"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s40123-025-01106-1"}],"container-title":["Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000549449","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T17:01:15Z","timestamp":1772730075000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000549449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,6]]},"references-count":18,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,3,2]]},"published-print":{"date-parts":[[2026,3,4]]}},"URL":"https:\/\/doi.org\/10.1159\/000549449","archive":["Portico"],"relation":{},"ISSN":["0030-3755","1423-0267"],"issn-type":[{"value":"0030-3755","type":"print"},{"value":"1423-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,6]]}}}