{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:54:29Z","timestamp":1777870469172,"version":"3.51.4"},"reference-count":87,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"abstract":"<jats:p>Introduction: With the aging global population, effective screening tools for age-related cognitive disorders are urgently needed. Mild cognitive impairment (MCI), a transitional stage between normal aging and dementia, requires early detection for timely intervention. Methods: The current research developed an innovative electronic assessment tool designed with three task modules targeting executive function, memory binding, and spatial navigation to quickly screen for MCI in older adults. A validation study was conducted with 271 older participants, aged 56 to 89, comprising 138 individuals with MCI and 133 cognitively normal controls. An independent dataset from a community hospital was used for further confirmation. Results: The validation study indicated excellent reliability and validity, achieving 72% accuracy in distinguishing MCI from cognitively normal individuals, with excellent screening power (AUC = 0.807; 95% CI: 0.756\u20130.858). This performance surpasses that of the paper-and-pencil Mini-Mental State Examination (MMSE). The independent dataset from a community hospital further confirmed that the tool achieved a good accuracy rate of 93% (26\/28) in predicting MCI. Conclusion: These results provide strong tool support for the early identification of MCI, enhancing the effective management of cognitive decline in at-risk elderly individuals.<\/jats:p>","DOI":"10.1159\/000549530","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T17:00:57Z","timestamp":1773766857000},"page":"1-17","source":"Crossref","is-referenced-by-count":0,"title":["Digital Cognitive Assessment for Older Adults: Validation of an Automated Three-Module Tool for Mild Cognitive Impairment and Dementia Screening"],"prefix":"10.1159","author":[{"given":"Dong-ni","family":"Pan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hailun","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juejing","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanjia","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dingyao","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gui","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2016.03.003"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(20)30185-7"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1080\/15622975.2019.1696473"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30367-6"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12217"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2018.05.010"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617721001314"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3389\/fdgth.2022.1029810"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610214002269"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.intell.2018.01.003"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186\/2050-7283-1-30"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2015_5001"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11144191"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000455831"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0611314104"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2022.111852"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-201447"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1076\/1380-3395(200008)22:4;1-0;FT518"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/psyg.12484"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1159\/000350806"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.390"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15135"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S53645"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1080\/23279095.2021.1871615"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2013.03.006"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2017.07.021"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14124041"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2019.03.014"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-018-1795-7"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.2196\/42637"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1159\/000095427"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.3.303"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12190"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2013.15.4\/hjahn"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00458"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2013.00012"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1037\/pag0000152"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00122"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1002\/alz.044596"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acx046"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-010-5484-9"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2011.03.022"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq148"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-022-01082-9"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14475"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1037\/neu0000825"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-180966"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1017\/s1041610298005365"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4656"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-018-0031-x"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-150855"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acz019"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2017.12.019"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1037\/neu0000072"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2015.03.004"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-200615"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1080\/13854046.2018.1535662"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1177\/1533317514522852"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1186\/s40359-024-02283-7"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2013.00094"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-019-0474-3"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.3758\/bf03193146"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-12-156"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2024.1369766"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.12114\/j.issn.1007-9572.2019.00.045"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1959.tb00467.x"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.23.1.56"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1177\/0891988719882102"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1017\/s1041610297004717"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-017-0254-x"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1080\/13854046.2013.809795"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1818430116"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-021-03495-6"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53221.x"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1992.tb01992.x"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000172958.95282.2a"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-132027"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1206481"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.01.023"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-200586"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt250"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1323"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1177\/15333175221117006"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-1-60"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.1093\/geroni\/igy038"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2008.07.003"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000549530","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T16:01:18Z","timestamp":1777564878000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000549530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,17]]},"references-count":87,"URL":"https:\/\/doi.org\/10.1159\/000549530","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.31788868","asserted-by":"subject"}]},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"value":"1420-8008","type":"print"},{"value":"1421-9824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,17]]}}}