{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T07:01:55Z","timestamp":1779260515492,"version":"3.51.4"},"reference-count":22,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologica"],"abstract":"<jats:p>Introduction: The bullous variant of central serous chorioretinopathy (bvCSC) represents a rare and severe manifestation of CSC. This study aims to evaluate the clinical features, underlying systemic factors, and outcomes of bvCSC through a multicentric study. Methods: A retrospective analysis was conducted on patients diagnosed with bvCSC across five tertiary eye centers. Demographic data, visual acuity (VA), treatment modalities, and follow-up outcomes were analyzed. A literature review was performed to contextualize the findings. Results: The study included 35 eyes from 25 patients (80% male), with a mean age of 47.7 \u00b1 12.2 years. Systemic comorbidities were identified in 60% of patients. Baseline VA was 1.18 \u00b1 0.89 logMAR. Serous retinal detachment resolved in 63% of eyes, but persistent subretinal fibrosis contributed to limited visual recovery. Treatment varied, with observation (37%) being the most common approach, followed by systemic eplerenone (17%) and focal laser (13%). Available data did not show a clear advantage of any treatment modality. Conclusion: The bvCSC is frequently associated with systemic conditions and has a guarded visual prognosis despite anatomical resolution in most cases. The study underscores the importance of early diagnosis and a tailored treatment to optimize outcomes in this severe CSC variant.<\/jats:p>","DOI":"10.1159\/000549637","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:02:00Z","timestamp":1763744520000},"page":"41-49","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Features and Outcomes of Bullous Central Serous Chorioretinopathy: A Multicentric Cohort Study"],"prefix":"10.1159","volume":"249","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1910-9976","authenticated-orcid":false,"given":"Andrea","family":"Montesel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Sacconi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luke","family":"Nicholson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1772-3558","authenticated-orcid":false,"given":"Jay","family":"Chhablani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"Yzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danial","family":"Mohabati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camiel J.F.","family":"Boon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3292-9581","authenticated-orcid":false,"given":"Giuseppe","family":"Querques","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,11,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(73)90887-8"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(86)90036-6"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-018-4015-8"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-199801000-00005"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.03.017"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2022.04.015"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S28239"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-020-01409-w"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.84.5.485"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/ICB.0000000000001522"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.01.031"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000837"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2021.100973"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200202000-00005"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1080\/09273940802702579"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(01)00925-4"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-6420(99)00141-4"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e31824d09a8"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-020-01560-4"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2010.182121"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-025-04473-0"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32981-2"}],"container-title":["Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000549637","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T17:01:17Z","timestamp":1772730077000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000549637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,21]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,3,2]]},"published-print":{"date-parts":[[2026,3,4]]}},"URL":"https:\/\/doi.org\/10.1159\/000549637","archive":["Portico"],"relation":{},"ISSN":["0030-3755","1423-0267"],"issn-type":[{"value":"0030-3755","type":"print"},{"value":"1423-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,21]]}}}