{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:06:06Z","timestamp":1780383966114,"version":"3.54.1"},"reference-count":24,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"abstract":"<jats:p>&lt;p&gt;Introduction: The primary aim of this study was to evaluate the total seizure burden (TSB) and maximum hourly seizure burden (MSB) before and after the administration of lidocaine (LDC) as add-on therapy in neonates with amplitude-integrated electroencephalography (aEEG)-confirmed seizures. Secondary aims were documenting the need for additional ASM at 4, 12, and 24 h after LDC and the rate of seizure freedom for at least 24, 48, and 72 h after LDC. Methods: This single-center, retrospective cohort study included neonates with persistent seizures after phenobarbital who received add-on LDC therapy. Neonates were monitored with a continuous 2-channel aEEG. The TSB and MSB were calculated using raw EEG data collected 4 h before and after the administration of LDC. Results: Sixty-one neonates were included. Seizure etiology consisted of hypoxic-ischemic encephalopathy (n = 24), hemorrhagic or ischemic stroke (n = 16), central nervous system infection (n = 7), genetic (n = 8), metabolic disorders (n = 4), and unknown etiology (n = 2). After LDC administration, median TSB decreased significantly from 31 (interquartile range [IQR] 16\u201368) to 0 min (IQR 0\u20130, p &lt; 0.01) and MSB from 10 (IQR 6\u201341) to 0 min\/h (IQR 0\u20130, p &lt; 0.01). The need for additional ASM was 3% (2\/61) within 4 h and 41% (25\/61) within 24 h. Seizure freedom after LDC was achieved in 71% (42\/59) for at least 24 h and 52% (29\/56) for 72 h. Discussion: LDC significantly reduced TSB and MSB in neonates with (a)EEG-confirmed seizures, achieving 100% seizure reduction in the majority, with half of the neonates remaining seizure-free for at least 72 h. &lt;\/p&gt;<\/jats:p>","DOI":"10.1159\/000549690","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T17:01:14Z","timestamp":1764349274000},"page":"145-153","source":"Crossref","is-referenced-by-count":2,"title":["Seizure Burden before and after Lidocaine as Add-On Therapy in (Amplitude-Integrated) Electroencephalography-Confirmed Neonatal Seizures"],"prefix":"10.1159","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1715-093X","authenticated-orcid":false,"given":"Mathies","family":"Rondagh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4701-1543","authenticated-orcid":false,"given":"Bregje O.","family":"van Oldenmark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"van Steenis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selma C.","family":"Tromp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratna N.G.B.","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Lopriore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5603-5697","authenticated-orcid":false,"given":"Sylke J.","family":"Steggerda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7282-8304","authenticated-orcid":false,"given":"Linda S.","family":"de 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