{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T17:05:14Z","timestamp":1767719114339,"version":"3.48.0"},"reference-count":32,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Dis"],"abstract":"<jats:p>Introduction: Oral anemia treatments are preferred by patients on home-based peritoneal dialysis (PD). We evaluated the effectiveness and safety of oral roxadustat in Chinese patients with chronic kidney disease (CKD)-associated anemia on PD. Methods: In this phase 4 study, patients with CKD-anemia on PD received roxadustat thrice weekly for 24 weeks. We assessed the proportion with hemoglobin \u2265100 g\/L at Weeks 20 and 24 (overall and stratified by type 2 diabetes mellitus [T2DM] vs. non-diabetes mellitus [DM]), quality of life changes according to the Functional Assessment of Cancer Therapy-Anemia (FACT-An), and 36-Item Short Form Health Survey (SF-36), and safety. Results: Overall, 195 patients (116 male [59.5%]; mean \u00b1 standard deviation age, 46.3 \u00b1 12.3 years) were enrolled; 189 (96.9%) were erythropoiesis-stimulating agent-treated and 43 (22.1%) had T2DM. Baseline hemoglobin was 98.1 \u00b1 10.7 g\/L and was &lt;80 g\/L in 10 (5.1%). The mean (95% confidence interval) proportion who achieved a hemoglobin concentration \u2265100 g\/L was 85.1% (79.8%, 90.5%) (T2DM: 89.2% [78.5%, 99.9%]; non-DM: 84.0% [77.8%, 90.1%]). The change in Total FACT-An score (baseline to Week 24), but not SF-36 scores, was clinically significant (\u22126.2 [\u22129.0, \u22123.4]), with a greater decrease in the T2DM subgroup. Residual renal function declined slightly from baseline to Week 24 (\u22120.2 mL\/min\/1.73 m2). Treatment-emergent adverse events occurred in 158 patients (81.0%) and were roxadustat-related in 20 (10.3%). Conclusion: Roxadustat corrected anemia in Chinese patients with CKD on PD, irrespective of baseline T2DM. Adverse events were consistent with roxadustat\u2019s known safety profile and with PD patients\u2019 characteristics.<\/jats:p>","DOI":"10.1159\/000549723","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T09:16:21Z","timestamp":1765358181000},"page":"1-17","source":"Crossref","is-referenced-by-count":0,"title":["NANLING: Roxadustat Effectiveness\/Safety in Chronic Kidney Disease-Associated Anemia with Peritoneal Dialysis"],"prefix":"10.1159","volume":"12","author":[{"given":"Zhiming","family":"Ye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiping","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0437-2015","authenticated-orcid":false,"given":"Xiao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenhua","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongtao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiqing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4943-7774","authenticated-orcid":false,"given":"Cuihua","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuting","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8624-744X","authenticated-orcid":false,"given":"Xueqing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The NANLING Working Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-022-00623-7"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2006.03.010"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/17.suppl_11.39"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl716"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2007.00810.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000506536"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfae075"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.4161\/cc.7.1.5145"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1901713"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfab051"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2020111638"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2021.04.007"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-021-01904-6"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.12888"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159\/000097600"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-018-0933-8"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1813599"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-022-02225-w"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e328335f939"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-017-0566-z"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-020-01912-8"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00096.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-021-02593-0"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1080\/13548506.2022.2119481"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V12102158"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5001910"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0242254"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2022.2050754"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-022-02367-z"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1159\/000516280"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-023-03119-z"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn441217-20220418-00158"}],"container-title":["Kidney Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000549723","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T17:00:59Z","timestamp":1767718859000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000549723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,24]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000549723","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.30703058","asserted-by":"subject"}]},"ISSN":["2296-9381","2296-9357"],"issn-type":[{"type":"print","value":"2296-9381"},{"type":"electronic","value":"2296-9357"}],"subject":[],"published":{"date-parts":[[2025,11,24]]}}}