{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T16:58:17Z","timestamp":1775840297919,"version":"3.50.1"},"reference-count":10,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Neurol"],"abstract":"<jats:p>Introduction: Stiff-person syndrome is a neurological disorder characterized by painful muscle cramps and progressive muscle spasticity. In patients with positive anti-amphiphysin antibodies, there is an association with malignancies such as breast carcinomas and small cell lung cancers. Case Presentation: We report the case of a 77-year-old male patient who developed symptoms of anti-amphiphysin positive stiff-person syndrome and was diagnosed with breast cancer. After immunomodulatory and curative-intent oncological treatment, the patient experienced marked improvement in his neurological symptoms. Conclusion: This case is an example of the importance of multidisciplinary care and thorough oncological workup in a case of stiff-person syndrome with positive anti-amphiphysin antibodies.<\/jats:p>","DOI":"10.1159\/000549746","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T17:00:57Z","timestamp":1764262857000},"page":"1-8","source":"Crossref","is-referenced-by-count":0,"title":["Stiff-Person Syndrome with Anti-Amphiphysin Antibodies: A Paraneoplastic Phenomenon Revealing Breast Cancer in a 77-Year-Old Male"],"prefix":"10.1159","volume":"18","author":[{"given":"Michael","family":"Geyskens","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dareia S.","family":"Roos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inge R.","family":"Konings","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathelijne","family":"Gorter de Vries","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieter","family":"Raijmakers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Schutte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-309201"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51791"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-009-0013-9"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.11995"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2011-000071"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.7916\/D85M65GD"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2019.06.021"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2020-237738"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-024-01012-3"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.94.15_supplement.1162"}],"updated-by":[{"DOI":"10.1159\/000551267","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000}}],"container-title":["Case Reports in Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000549746","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T17:00:43Z","timestamp":1766509243000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000549746"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,25]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000549746","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.30689090","asserted-by":"subject"}]},"ISSN":["1662-680X"],"issn-type":[{"value":"1662-680X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,25]]}}}