{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T08:46:37Z","timestamp":1769157997002,"version":"3.49.0"},"reference-count":14,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Ophthalmol"],"abstract":"<jats:p>Introduction: In this study, we report a case of an acquired fixed vitreous cyst associated with a pigmented epiretinal membrane (ERM) that developed approximately 10 years after vitrectomy for vitreous hemorrhage (VH) secondary to branch retinal vein occlusion (BRVO). Case Presentation: This study involved an 85-year-old male who had previously undergone a vitrectomy in November 2014 for a VH caused by BRVO. The patient\u2019s postoperative recovery was favorable; however, at a follow-up visit in January 2023, a pigmented ERM was observed, along with an adjacent cyst approximately one-third optic disc diameter. Initially, the lesion presented as cystoid macular edema (CME) with multiple cystoid spaces, one of which that had gradually enlarged and eventually formed into a pigmented vitreous cyst of approximately two optic disc diameters in size by January 2025. The cyst was surgically excised, and histological analysis revealed that the cyst wall demonstrated a bilayered structure; i.e., the outer layer consisting of retinal pigment epithelial (RPE), while the inner layer being composed of glial lineage cells. Conclusion: Based on our findings, we hypothesize that the wall of a cystoid space in CME formed a protrusion from the retina into the vitreous cavity, which subsequently developed into a vitreous cyst through migration and proliferation of reactive M\u00fcller cells and RPE cells due to structural compromise of the retina.<\/jats:p>","DOI":"10.1159\/000550002","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T17:00:39Z","timestamp":1766163639000},"page":"97-104","source":"Crossref","is-referenced-by-count":0,"title":["Histopathological Analysis of an Acquired Vitreous Cyst with Pigmented Epiretinal Membrane following Vitrectomy: A Case Report"],"prefix":"10.1159","volume":"17","author":[{"given":"Tsunehiko","family":"Ikeda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimitoshi","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seita","family":"Morishita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bumpei","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natsumi","family":"Miyashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayami","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomomi","family":"Hama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayumu","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Fushimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3928\/0191-3913-19780101-10"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-017-0580-6"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1177\/112067210401400213"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-6420(85)34042-3"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2022.5034"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3928\/23258160-20170928-13"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-015-0405-1"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.4103\/meajo.MEAJO_101_19"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-6420(00)00519-4"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-199616030-00012"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.30714"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/APO.0000000000000574"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/BF00927264"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-010-1900-z"}],"container-title":["Case Reports in Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000550002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T17:00:54Z","timestamp":1769101254000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000550002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,19]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000550002","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.30918887","asserted-by":"subject"}]},"ISSN":["1663-2699"],"issn-type":[{"value":"1663-2699","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,19]]}}}