{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T06:26:03Z","timestamp":1769581563839,"version":"3.49.0"},"reference-count":40,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Surg Res"],"abstract":"<jats:p>Introduction: Wound healing is a complex biological process involving hemostasis, inflammation, proliferation, and tissue remodeling. Despite promising results with platelet-rich plasma (PRP) and synthetic scaffolds used separately, their combined in vivo effects remain insufficiently investigated. This experimental study presents the first results on a composite wound dressing integrating PRP, rich in growth factors, with electrospun polyvinyl alcohol (PVA) nanofibers, a biocompatible and stable polymer. Methods: Full-thickness skin defects (1 \u00d7 1 cm2) were created in 21 adult female Sprague-Dawley rats and divided into three groups: control, PVA, and PRP\/PVA. Wound healing was assessed histologically and biochemically on days 7 and 14, including fibroblast growth factor-2 (FGF-2) measurement. Results: The PRP\/PVA group showed enhanced epithelialization and angiogenesis compared to other groups (p &lt; 0.05), along with higher FGF-2 levels. Conclusion: The relatively small sample size, absence of a PRP-only group, and short observation period limit the generalizability of these findings. Within these constraints, the results indicate a potential synergistic role of PRP and PVA scaffolds in promoting wound repair, supporting further studies with larger cohorts and standardized PRP preparation before clinical translation.<\/jats:p>","DOI":"10.1159\/000550016","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T17:00:53Z","timestamp":1767200453000},"page":"56-65","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Platelet-Rich Plasma and Polyvinyl Alcohol Wound Dressing in Open Wound Healing: First Results from an Experimental Rat Model"],"prefix":"10.1159","volume":"67","author":[{"given":"Umit Akin","family":"Dere","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma","family":"Altintas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baris","family":"Albuz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazli","family":"\u00c7il","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pelin","family":"Kuzucu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esin","family":"Avci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hande","family":"Senol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"Koluman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Erdal","family":"Coskun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,12,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12080735"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-55214-7"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.08.002"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000002728"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1067-1927.2005.1304S1.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.reth.2024.06.003"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkaa028"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2003.12.003"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2023.120924"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2014.03.065"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2021.112541"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1023\/a:1024907615244"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509359125"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1080\/09205063.2019.1582270"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202200014"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.matpr.2019.03.214"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1021\/la300049j"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-011-1221-0"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12123890"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1039\/d2ra03214g"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1089\/ten.TEB.2018.0309"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3886(95)00041-8"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2006.00173.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd003556.pub2"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13344"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-49132-x"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.34172\/bi.2021.28"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.4037\/ccn2015658"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.7399\/fh.2015.39.3.7998"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1097\/00008505-200110000-00002"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2008.11.009"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S268941"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12683"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2005.01.004"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2020.1232"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S96968"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2021.0124"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.2217\/rme-2016-0031"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1002\/wdev.176"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2021.11.003"}],"container-title":["European Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000550016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T17:01:43Z","timestamp":1769533303000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000550016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,31]]},"references-count":40,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000550016","archive":["Portico"],"relation":{},"ISSN":["0014-312X","1421-9921"],"issn-type":[{"value":"0014-312X","type":"print"},{"value":"1421-9921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,31]]}}}