{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T17:02:49Z","timestamp":1777482169424,"version":"3.51.4"},"reference-count":26,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Surg Res"],"abstract":"<jats:p>Introduction: This meta-analysis investigated differences in rebound pain and opioid consumption when using brachial plexus blockade (BPB) versus general anesthesia (GA) for upper limb surgery. Methods: Four databases were searched. Odds ratios (OR), mean differences (MD), and standard mean differences (SMD) with 95% confidence intervals (CIs) were calculated. Outcomes included were pain, opioid consumption, adverse events, and discharge time. The risk of bias was assessed. Results: Nine clinical trials involving 487 patients were included. BPB resulted in significantly lower pain scores within 2 h postoperatively (MD \u22124.57, 95% CI \u22125.76 to 3.38; participants = 263; studies = 5; I2 = 0%; p &lt; 0.00001) but not from 6 to 24 h. Opioid consumption (mg) was lower in the BPB group in the first 24 h (SMD \u22120.85, 95% CI \u22121.41 to \u22120.29; participants = 188; studies = 3; I2 = 67%; p &lt; 0.003). BPB was associated with fewer postoperative nausea\/vomiting events (OR 0.19, 95% CI 0.10\u20130.33; participants = 326; studies = 6; I2 = 45%; p &lt; 0.00001) and shorter hospital stay (SMD \u22121.20, 95% CI \u22121.73 to \u22120.66; participants = 213; studies = 4; I2 = 69%; p &lt; 0.0001). There was no difference in the number of patients not requiring opioids from 24 to 48 h. Conclusions: BPB provided superior pain control at 2 h postoperatively and was associated with reduced opioid use, fewer adverse events, and shorter discharge time. No significant differences in pain scores were observed at 6\u201324 h or beyond 24 h, likely due to block wear-off. Despite this limitation, BPB still offered perioperative advantages over GA.<\/jats:p>","DOI":"10.1159\/000550121","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T17:00:51Z","timestamp":1766422851000},"page":"66-76","source":"Crossref","is-referenced-by-count":1,"title":["Brachial Plexus Blockage versus General Anesthesia for Upper Extremity Surgery: A Systematic Review and Meta-Analysis"],"prefix":"10.1159","volume":"67","author":[{"given":"Rafael","family":"Llombart-Blanco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Benlloch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gonzalo","family":"Mariscal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Vera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Egor","family":"Polevoi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Dway","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Barrios","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Llombart-Ais","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16183257"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200407000-00020"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.5144\/0256-4947.2023.339"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11216386"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.18.00984"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.9434"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2021.11.054"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00590-014-1483-3"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2007.01504.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/86.2.272"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.38552"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200505000-00020"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000436607.40643.0a"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/aas.14318"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.rapm.2005.02.009"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19159155"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318267ef31"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-016-4735-1"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aep173"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-023-02038-8"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2020.02.048"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2012.08.001"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000035522"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e3181a3e721"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2005.00708.x"}],"container-title":["European Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000550121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T17:01:35Z","timestamp":1769533295000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000550121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,22]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000550121","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.30932609","asserted-by":"subject"}]},"ISSN":["0014-312X","1421-9921"],"issn-type":[{"value":"0014-312X","type":"print"},{"value":"1421-9921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,22]]}}}