{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T16:18:01Z","timestamp":1780330681149,"version":"3.54.1"},"reference-count":16,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"<jats:p>Introduction: Natural killer\/T-cell (NK\/T) lymphomas are very rare with poor prognosis. These cancers are more prevalent in Asian and South American populations, are often Epstein-Barr virus positive, and usually involve the nasal cavity or paranasal sinuses. NK\/T lymphomas originating from the orbit is an extremely rare occurrence. Case Presentation: Here we report the clinical, radiological, and histopathologic features of an 18-year-old male who presented with a painful right orbital mass associated with ipsilateral headache and complete vision loss in the affected eye, that was histologically diagnosed as an NK\/T lymphoma. Despite a favorable response to gemcitabine, dexamethasone, and cisplatin treatment, the patient died as a result of treatment-induced complications. We present the clinical and radiologic parameters, the histological and molecular characterization of the tumor, including treatment and outcome. Conclusion: This case underscores the importance of promptly characterizing atypical orbital masses, maintaining a high index of suspicion for NK\/T lymphoma in the differential diagnosis even for young patients, the need for safer targeted treatments especially in resource-limited settings, and the need for close monitoring of side effects during treatment.<\/jats:p>","DOI":"10.1159\/000550181","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T17:00:34Z","timestamp":1767373234000},"page":"211-217","source":"Crossref","is-referenced-by-count":2,"title":["Primary Orbital Extranodal Natural Killer\/T-Cell Lymphoma in a Young African Male: A Case Report"],"prefix":"10.1159","volume":"19","author":[{"given":"George","family":"Pupwe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Julius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chibamba","family":"Mumba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guobin","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6917-3888","authenticated-orcid":false,"given":"Sody","family":"Munsaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0648-4128","authenticated-orcid":false,"given":"Owen","family":"Ngalamika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,1,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2016.1206465"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000449227"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-025-13761-5"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.1384"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0b013e3181659867"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2020-238113"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11237010"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-017-0452-9"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-99716-2_8"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-0153"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.8295"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2016(04)05"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13061414"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-02515-5"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-12-756841"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.51.5304"}],"container-title":["Case Reports in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000550181","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T17:00:36Z","timestamp":1769619636000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000550181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,2]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000550181","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.30985564","asserted-by":"subject"}]},"ISSN":["1662-6575"],"issn-type":[{"value":"1662-6575","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,2]]}}}