{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T17:57:59Z","timestamp":1772215079514,"version":"3.50.1"},"reference-count":23,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebrovasc Dis"],"abstract":"<jats:p>Introduction: The pathophysiological basis of brain arteriovenous malformations (bAVMs) remains incompletely understood. Early-life factors are hypothesized to influence cerebrovascular development; however, their potential associations with bAVMs have not been systematically evaluated. This study aimed to investigate the associations between eight early-life factors and the risk of bAVMs. Methods: This prospective cohort study included 329,121 participants aged 40\u201369 years from the UK Biobank with complete covariate data at baseline. Multiple-adjusted logistic regression models were used to explore the associations between eight self-reported early-life factors (breastfed as a baby, part of a multiple birth, maternal smoking around birth, comparative body size at age 10, handedness, childhood sunburn occasions, number of older siblings, birth weight) and subsequent diagnosis of bAVMs. Results: A total of 141 patients were diagnosed with bAVMs. After multivariable adjustment, three early-life factors were associated with an increased risk of bAVMs: very low birth weight (&lt;1.5 kg vs. 2.5\u20134.0 kg; odds ratio [OR], 3.27; 95% confidence interval [CI], 1.04\u201310.67), having one or more older siblings (\u22651 person vs. none; OR, 1.83; 95% CI, 1.03\u20133.24), and frequent childhood sunburn (&gt;10 episodes vs. none; OR, 2.83; 95% CI, 1.13\u20137.08). No statistically significant associations were observed in other early-life factors. Sensitivity analyses confirmed the robustness of these findings. Conclusions: In this large prospective cohort, very low birth weight, the presence of older siblings, and repeated childhood sunburn were associated with a higher risk of bAVMs. These findings warrant validation and further investigation into the underlying biological mechanisms.<\/jats:p>","DOI":"10.1159\/000550221","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T17:00:56Z","timestamp":1769014856000},"page":"1-8","source":"Crossref","is-referenced-by-count":0,"title":["Early-Life Factors and Risk of Brain Arteriovenous Malformations: A Prospective Cohort Study"],"prefix":"10.1159","author":[{"given":"Zhisheng","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuge","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaoyao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanyue","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengna","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiancheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weixi","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junxia","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.8"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000010968"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-200008000-00023"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3171\/2020.7.PEDS20447"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199906103402307"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2008.11.002"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2012.02.005"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2021.06.050"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/s0190-9622(81)70103-8"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.173229"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1037\/\/0003-066x.56.6-7.497"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1080\/01688639408402690"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwac223"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000368605"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-020-0829-z"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.121.035640"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1136\/jech.57.5.385"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-020-02261-z"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws589"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12874666"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31179-X"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmr022"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01024-7"}],"container-title":["Cerebrovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000550221","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T17:00:53Z","timestamp":1772211653000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000550221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,21]]},"references-count":23,"URL":"https:\/\/doi.org\/10.1159\/000550221","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.31112776","asserted-by":"subject"}]},"ISSN":["1015-9770","1421-9786"],"issn-type":[{"value":"1015-9770","type":"print"},{"value":"1421-9786","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,21]]}}}