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Despite its wide application in traditional medicine, its mechanisms of action and safety profile require further investigation. Summary: The key contributions of this review lie in: (1) the first systematic integration of WED\u2019s multi-target mechanisms across diseases through the AMPK\/NF-\u03baB\/NLRP3 network; (2) clarification of its dose-effect relationship (effective therapeutic window: 5\u2013100 mg\/kg) and toxicity thresholds; (3) proposal of clinical translation strategies, including nanodelivery systems to address bioavailability issues. Recent studies revealed novel mechanisms such as WED\u2019s inhibition of ferroptosis via GPX4 and modulation of the FXR-bile acid axis, demonstrating efficacy in acute lung injury and liver fibrosis. Key Messages: This article provides a comprehensive framework integrating mechanistic insights and translational research for WED\u2019s clinical development.<\/jats:p>","DOI":"10.1159\/000550254","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T17:01:50Z","timestamp":1770138110000},"page":"135-144","source":"Crossref","is-referenced-by-count":0,"title":["Wedelolactone: Unveiling the Multifaceted Anti-Inflammatory 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