{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T16:58:42Z","timestamp":1780937922012,"version":"3.54.1"},"reference-count":45,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"abstract":"<jats:p>Introduction: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by recurrent painful nodules, abscesses, and tunnels, primarily affecting intertriginous areas. While IL-17-targeting biologics, including bimekizumab and secukinumab, have shown efficacy in moderate-to-severe HS, data in Asian populations remain limited. The aim of our study was to assess the clinical efficacy of secukinumab in Korean patients with moderate-to-severe HS and to perform an exploratory analysis of treatment-associated transcriptomic changes. Methods: Twenty-five patients with moderate-to-severe HS enrolled in a Managed Access Program (MAP) cohort received secukinumab 300 mg\/week for 4 weeks, and then every 2 weeks through week 16. Clinical outcomes were assessed every 4 weeks. Paired lesional skin biopsies (baseline and week 12) from 3 patients underwent RNA sequencing to evaluate transcriptomic changes. Results: At week 16, 86.96% of patients achieved Hidradenitis Suppurativa Clinical Response (HiSCR), 78.26% reached a \u226555% reduction in the International Hidradenitis Suppurativa Severity Score System (IHS4 55), and 81.81% reported a \u226530% improvement in skin pain on the Numeric Rating Scale (NRS-30). Transcriptomic analysis revealed downregulation genes involved in epidermal development, keratinocyte differentiation, and antimicrobial response and upregulation of cell cycle-related pathways. Conclusions: Secukinumab demonstrated substantial clinical efficacy and modulated disease-relevant molecular pathways in Korean patients with moderate-to-severe HS. These findings support its therapeutic potential in Asian populations and provide mechanistic insights into IL-17 blockade in HS.<\/jats:p>","DOI":"10.1159\/000550262","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T17:00:45Z","timestamp":1769446845000},"page":"284-295","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and Transcriptomic Response to Secukinumab in Korean Patients with Moderate-to-Severe Hidradenitis Suppurativa"],"prefix":"10.1159","volume":"242","author":[{"given":"Sujin","family":"Moon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young In","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Ah","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji 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