{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T19:04:42Z","timestamp":1772651082185,"version":"3.50.1"},"reference-count":17,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebrovasc Dis"],"abstract":"<jats:p>Introduction: The aim of this study was to establish the score for predicting the 5-year risk of hemorrhagic stroke in patients with asymptomatic moyamoya disease (MMD) using the Asymptomatic Moyamoya Registry (AMORE) data and to evaluate its reproducibility. Methods: The AMORE study was a prospective cohort study that recruited participants from 18 centers in Japan. A total of 103 patients completed the 5-year follow-up and of these, 6 patients experienced hemorrhagic stroke. According to the results of multivariate analysis, we selected age \u226546 years, grade-2 choroidal anastomosis, and microbleeds as variables in the prediction model. The cumulative rates of hemorrhagic stroke were estimated per hemisphere using the Kaplan-Meier method. Nonparametric bias-corrected confidence intervals (CIs) based on the Bootstrap sample were calculated to assess the reproducibility of the 5-year risk of hemorrhagic stroke. Results: We created the AMORE score (0\u20133 points) to estimate the 5-year risk of hemorrhage with 1 point for each of age \u226546 years, grade-2 choroidal anastomosis, and microbleeds. The AMORE score was applied to a total of 135 MMD hemispheres. The 5-year risk of hemorrhagic stroke per hemisphere was 1.8%, 1.6%, 15.4%, and 50.0% for AMORE scores of 0, 1, 2, and 3, respectively. The cumulative rate of hemorrhagic stroke for AMORE score 3 was significantly higher than for AMORE score 0 (hazard ratio [HR], 38.7; 95% CI, 3.45\u2013433; p = 0.003) and score 1 (HR, 41.8; 95% CI, 3.74\u2013468; p = 0.002). The corresponding 90% CIs were 0%\u20135.6%, 0%\u20135.2%, 0%\u201338.5%, and 0%\u2013100%, and the corresponding 80% CIs were 0%\u20134.7%, 0%\u20134.5%, 5.9%\u201333.3%, and 23%\u2013100% for AMORE scores 0, 1, 2, and 3, respectively. Conclusion: The 5-year risk of hemorrhagic stroke in patients with asymptomatic MMD can be adequately estimated using the AMORE score.<\/jats:p>","DOI":"10.1159\/000550273","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T17:00:47Z","timestamp":1769792447000},"page":"1-7","source":"Crossref","is-referenced-by-count":0,"title":["The AMORE Score for Predicting the 5-Year Risk of Hemorrhagic Stroke in Asymptomatic Moyamoya Disease"],"prefix":"10.1159","author":[{"given":"Tomohito","family":"Hishikawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Murai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi 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