{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:02:35Z","timestamp":1790186555511,"version":"4.1.0"},"reference-count":20,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"abstract":"<jats:p>Introduction: The aim of the study was to evaluate functional and anatomical changes at the 44-week follow-up in patients with na\u00efve neovascular age-related macular degeneration (nAMD) treated with faricimab intravitreal injections (IVIs). Methods: Fifty-four eyes of 54 patients with na\u00efve active macular neovascularization and nAMD were enrolled at the Ophthalmology Clinic of University \u201cG. d\u2019Annunzio,\u201d Chieti-Pescara, Italy. All patients were scheduled for faricimab IVI. Each patient underwent complete ophthalmic examination including best-corrected visual acuity (BCVA) using the Early Treatment Diabetic Retinopathy Study (ETDRS) charts and optical coherence tomography. All measurements were evaluated at baseline, at week 20 and then according to fixed retreatment interval up to week 44. Fluorescein angiography and indocyanine green angiography were also performed at baseline. Main outcome measures were changes in BCVA, central macular thickness (CMT), subfoveal choroidal thickness (SFCT), intraretinal fluid presence, subfoveal subretinal fluid presence and thickness, the presence of pigment epithelial detachments (PEDs), and its maximum height (PED-MH). Results: BCVA improved and CMT reduced significantly from baseline to week 44 (p = 0.002 and p = 0.020, respectively) in the overall sample with a higher significant improvement from baseline to week 20 (p &lt; 0.001 for both parameters) and no additional significant improvement from week 20 to week 44 in the overall sample (p = 0.348 and p = 0.146, respectively). At week 20, 72.3% of patients were in the Q12\/Q16 interval. Patients in the Q8 interval showed significant improvement in BCVA (p &lt; 0.001) and significant reduction of CMT (p = 0.008) from baseline to week 44, respectively. PED-MH as well showed a significant reduction from baseline to week 44 (p &lt; 0.001). Patients in the Q12 interval showed significant improvement in BCVA (p = 0.030) and significant reduction of CMT, SFCT, and PED-MH from baseline to week 36 (p &lt; 0.001). Patients in the Q16 interval showed significant reduction of BCVA during follow-up (p = 0.026). CMT, SFCT, and PED-MH were significantly reduced from baseline to week 44 (p &lt; 0.001). Conclusion: Faricimab showed efficacy in the treatment of na\u00efve nAMD patients with an improvement of many anatomical and functional parameters at 44 weeks, allowing the maintenance of a treatment regimen for most patients equal to or greater than 12 weeks.<\/jats:p>","DOI":"10.1159\/000550307","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T17:01:53Z","timestamp":1770138113000},"page":"74-82","source":"Crossref","is-referenced-by-count":1,"title":["Long-Term Follow-Up of Faricimab Intravitreal Injections in Na\u00efve Neovascular Age-Related Macular Degeneration"],"prefix":"10.1159","volume":"69","author":[{"given":"Luca","family":"Belloni Baroni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Toto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Formenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzia","family":"Passamonti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Quarta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5856-6686","authenticated-orcid":false,"given":"Maria Ludovica","family":"Ruggeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Aloia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Di Nicola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Mastropasqua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(13)70145-1"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp2102061"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-017-3647-4"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2018.2019"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.xops.2021.100076"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000540194"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2019.11.004"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.33393\/dti.2024.3213"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-023-00985-w"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S409822"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-35759-4"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2015.04.012"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-1229"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2016.03.039"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s40123-024-01005-x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.02.022"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-59632-0"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-59894-8"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aau6732"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.122.318151"}],"container-title":["Ophthalmic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000550307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T17:01:13Z","timestamp":1773766873000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000550307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,3]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000550307","archive":["Portico"],"relation":{},"ISSN":["0030-3747","1423-0259"],"issn-type":[{"value":"0030-3747","type":"print"},{"value":"1423-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,3]]}}}