{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T16:12:56Z","timestamp":1784045576232,"version":"3.55.0"},"reference-count":41,"publisher":"S. Karger AG","issue":"8","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"abstract":"<jats:p>Introduction: In studies, weight loss is strongly associated with outcomes in metastatic non-squamous cell lung cancer (mNSCLC). This work examines weight variations in first-line treatment, exploring their mechanisms based on treatment type, age, sex, weight loss, and excess weight before treatment. Methods: A retrospective analysis was conducted on patients undergoing first-line treatment. Weight was recorded at four points: before treatment (Wbe), day 1 of treatment (Wd1), 3 months into immune checkpoint inhibitors (ICIs) treatment or maintenance (W3mo), and at progression diagnosis (Wpro). Results: Among patients (n = 198), 47% received chemotherapy (CT) with ICIs, 26% CT alone, and 27% ICIs alone. At Wd1, 32% were overweight\/obese (body mass index kg\/m2) (BMI \u2265 25). Weight loss \u2265 5% before treatment was observed in 37%. Mean (SD) weight variations between Wd1 and W3mo were \u22121.1% (4.6) (CT), \u22120.2% (7.1) (CT+ICIs), and +0.4% (7.7) (ICIs alone) (p = 0.52). Patients older than 70 compared to \u226470 lost more weight between Wd1 and Wpro (\u22124.7% vs. \u22120.4%) (p = 0.019). Patients with pre-treatment weight loss \u2265 5% compared to those without weight loss stabilized or gained weight during treatment (+2.1% vs. \u22121.5%) (p = 0.009). Patients with BMI \u2265 25 lost more weight during treatment than those with BMI &lt;25 (\u22121.4% vs. +0.8%) (p = 0.024). Conclusion: Weight variations did not differ significantly across treatment types. Older patients are nutritionally more vulnerable. Pre-treatment significant weight loss \u2265 5% patients stabilized or gained weight during treatment, unlike those without initial weight loss. Pre-treatment weight loss in first-line mNSCLC supports, rather than contraindicates, cancer therapy. Higher BMI was associated with greater weight loss during treatment.<\/jats:p>","DOI":"10.1159\/000550347","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T17:00:49Z","timestamp":1772470849000},"page":"891-899","source":"Crossref","is-referenced-by-count":0,"title":["Weight Variations during First-Line Systemic Treatment of Metastatic Non-Small Cell Lung Cancer: New Paradigms from Real-World 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