{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T01:58:52Z","timestamp":1784599132974,"version":"3.55.0"},"reference-count":36,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"abstract":"<jats:p>Introduction: Hereditary angioedema due to C1 inhibitor deficiency (HAE-C1INH) has a substantial impact on patients\u2019 health-related quality of life (HRQoL). While generic instruments are frequently used for assessment, they may not fully capture the disease-specific burden. This study aimed to evaluate HRQoL in patients with HAE-C1INH types I and II using validated, angioedema-specific tools. The aims of the study were to assess HRQoL and disease control in patients with HAE-C1INH using validated angioedema-specific tools and secondarily to explore the association between attack localization and domain-specific quality-of-life impairments. Methods: In this multicenter cross-sectional study, 82 patients with HAE-C1INH from six referral centers completed the Angioedema Control Test (AECT), Angioedema Activity Score (AAS)-28, and Angioedema Quality of Life questionnaire (AE-QoL). Family screening was conducted among those who consented. Results: Patients experiencing attacks in the extremities (p &lt; 0.001) and laryngeal\/pharyngeal regions (p = 0.028) had significantly lower AECT scores, indicating poorer disease control. Higher AAS-28 scores were associated with attacks in the extremities (p = 0.008), abdomen (p = 0.018), face\/neck (p = 0.004), larynx\/pharynx (p &lt; 0.001), and tongue\/uvula\/palate (p &lt; 0.001). AE-QoL scores revealed impaired quality of life across all attack locations. Subdomain analysis showed that abdominal attacks significantly impacted the functioning (p = 0.005) and food (p = 0.037) domains. Attacks involving the face\/neck and larynx\/pharynx were associated with substantial impairment in fatigue\/mood (p = 0.002, p = 0.003), functioning (p = 0.044, p = 0.002), and fears\/shame (p = 0.039, p = 0.005) subdomains. Conclusion: While attack frequency and disease control remain the primary determinants of HRQoL in HAE-C1INH, our findings indicate that attack localization is associated with distinct domain-specific quality-of-life impairments. Beyond assessing attack frequency, the use of disease-specific QoL tools allows for the identification of domain-specific impairments. Personalized treatment strategies targeting both symptom control and quality-of-life domains are essential for alleviating the long-term burden on patients and their families.<\/jats:p>","DOI":"10.1159\/000550399","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T17:00:53Z","timestamp":1767891653000},"page":"1-11","source":"Crossref","is-referenced-by-count":1,"title":["A Comprehensive Assessment of Health-Related Quality of Life in Hereditary Angioedema as a Patient-Centered Approach"],"prefix":"10.1159","author":[{"given":"Ezgi","family":"Yalcin 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