{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:18:25Z","timestamp":1791332305818,"version":"4.3.1"},"reference-count":41,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychother Psychosom"],"abstract":"<jats:p>Introduction: Obsessive-compulsive disorder (OCD) is an often chronic and disabling mental disorder. Cognitive-behavioral therapy and serotonin-reuptake inhibitors and their combination are first-line treatments. However, about 50% of the patients do not achieve response or remission, although many patients received additional pharmacotherapy. These results highlight the need for additional evidence-based treatment options. Methods: In a randomized controlled trial (RCT), a manual-guided method of short-term psychodynamic therapy (STPP) for OCD was tested against a waiting list condition. Thirty-seven unmedicated patients were randomly assigned to STPP, 30 to the waiting list. The Yale-Brown Obsessive Compulsive Scale (Y-BOCS) total score post-therapy assessed by trained and masked raters was the primary outcome. Secondary outcomes included response, remission, depression, interpersonal problems, and obsessive beliefs. Results: In the intention-to-treat sample, STPP achieved a significantly lower Y-BOCS score (p &lt; 0.0001) than the waiting list condition, associated with a large between-group effect size (d = 1.04). The mean difference of change in the Y-BOCS between baseline and post-therapy or waiting period assessment was \u221211.49 (95% CI \u221214.36, \u22128.63) for STPP and \u22121.10 (95% CI \u22124.29, 2.10) in the waiting list. Remission rates were 60% vs. 20% (p = 0.0006), response rates 64% vs. 16% (p = 0.0003) in favor of STPP. Conclusion: In a first RCT, manual-guided STPP proved to be efficacious in OCD with a clinically meaningful improvement, thereby broadening the spectrum of evidence-based interventions. Of note, our study is one of the few trials using psychotherapy as a monotherapy in OCD, showing effects of psychotherapy alone. Further research is needed to confirm these first findings and to compare STPP with other established treatments.<\/jats:p>","DOI":"10.1159\/000550421","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T17:01:03Z","timestamp":1767978063000},"page":"1-13","source":"Crossref","is-referenced-by-count":3,"title":["Short-Term Psychodynamic Therapy of Obsessive-Compulsive Disorder: A Randomized Controlled Trial of Unmedicated Patients"],"prefix":"10.1159","author":[{"given":"Falk","family":"Leichsenring","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Steinert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Biskup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lila 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