{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T18:02:38Z","timestamp":1772560958871,"version":"3.50.1"},"reference-count":12,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"<jats:p>Introduction: Epstein-Barr virus (EBV)-positive inflammatory follicular dendritic cell sarcoma (EBV+ inflammatory FDCS) is a rare neoplasm that occurs almost exclusively in the spleen and liver. Although EBV+ inflammatory FDCS is recognized to show indolent behavior, its pathophysiology including the pathogenesis remains unclear. Case Presentation: We present an EBV+ inflammatory FDCS, which occurred in the spleen of a patient under the follow-up for chemotherapy against lung carcinoma. Sequential CT examinations reveal that a splenic lesion was first detectable 5 years after chemotherapy and has grown for another 3 years to form a mass of 4 cm in diameter. Splenectomy was performed. Histologically, a well-circumscribed lesion in the spleen exhibited the significant infiltration of lymphocytes and plasma cells in the background of hyalinized fibrous tissue, and large oval-shaped cells were intermingled with lymphocytes and plasma cells. Large oval-shaped cells were found to express CD21 and CD23, and they were shown to be positive for EBV-encoded small RNA in situ hybridization. Based on these findings, the splenic lesion was diagnosed as EBV+ inflammatory FDCS. Conclusion: The present case might provide information to discuss the possible pathogenesis of EBV+ inflammatory FDCS in the context of immunosuppression.<\/jats:p>","DOI":"10.1159\/000550533","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T17:00:53Z","timestamp":1769101253000},"page":"293-301","source":"Crossref","is-referenced-by-count":0,"title":["Epstein-Barr Virus-Positive Inflammatory Follicular Dendritic Cell Sarcoma Occurring in Spleen of a Patient after Chemotherapy for Lung Carcinoma: A Case Report"],"prefix":"10.1159","volume":"19","author":[{"given":"Takushi","family":"Morishige","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsutoshi","family":"Hirazawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisayuki","family":"Osoreda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200106000-00003"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01620-2"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.21037\/jgo-24-483"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/jscr\/rjae600"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e32997"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-024-01457-6"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1053\/j.sult.2006.06.003"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2016.12.043"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12057"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001632"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1603496"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186\/s40164-025-00655-2"}],"container-title":["Case Reports in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000550533","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T17:06:12Z","timestamp":1772557572000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000550533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,22]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000550533","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.31120990","asserted-by":"subject"}]},"ISSN":["1662-6575"],"issn-type":[{"value":"1662-6575","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,22]]}}}