{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T16:43:39Z","timestamp":1777308219753,"version":"3.51.4"},"reference-count":15,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologica"],"abstract":"<jats:p>&lt;p&gt;Introduction: Proliferative vitreoretinopathy (PVR) is the leading cause of surgical failure in rhegmatogenous retinal detachment (RRD) and is associated with poor visual prognosis. We aimed to report changes in VFQ-25 and SF-36 tests following surgery for PVR-RRD and identify clinical and demographic factors associated with recovery. Methods: This is a post hoc analysis of a phase IIIb randomized, participant-masked clinical trial evaluating slow-release dexamethasone in PVR-RRD. Patients underwent pars plana vitrectomy with silicone oil tamponade. Vision-related QOL was assessed using VFQ-25, and SF-36 test, at baseline, 6 months, and 12 months postoperatively. VFQ-25 subscales and SF-36 domains were analysed descriptively and with nonparametric paired tests; associations with best-corrected visual acuity (BCVA, logMAR) and other variables were assessed using Spearman correlation and nonparametric tests. Results: A total of 139 patients were included (mean age 61 years; 60% male). VFQ-25 total score improved from a median of 65.5 at baseline to 70 at 12 months (p = 0.0004). SF-36 total score improved from 68 to 77.5 at 12 months (p = 0.006). Worse 12-month BCVA correlated with lower VFQ-25 (p &lt; 0.001) and showed a borderline association with SF-36 (p = 0.054). In univariable analyses, women reported lower 12-month QOL; however, gender associations were attenuated in multivariable models (VFQ-25: \u03b2 = \u22124.39, p = 0.073; SF-36: \u03b2 = \u22124.71, p = 0.199). Retinal anatomical status and number of surgeries were not associated with QOL outcomes. Subscale\/domain analyses showed the largest improvements in psychosocial domains: VFQ-25 mental health increased from 50.0 to 68.8 (p = 3.35 \u00d7 10\u22125), and SF-36 mental health increased from 68.0 to 80.0 (p = 2.38 \u00d7 10\u22126), while most physical health domains were stable. Conclusions: Despite the complexity of PVR-RRD, significant improvements in both visual function and general QOL were observed postoperatively driven largely by psychosocial recovery. Final BCVA and baseline QOL had a greater influence on perceived recovery than anatomical success or number of surgeries. These findings highlight the importance of personalized care and rehabilitation in managing PVR-RRD patients. &lt;\/p&gt;<\/jats:p>","DOI":"10.1159\/000550679","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T17:01:06Z","timestamp":1769706066000},"page":"175-181","source":"Crossref","is-referenced-by-count":0,"title":["Patient-Reported Outcomes after Surgery for Proliferative Vitreoretinopathy: Post hoc Analysis of a Randomized Controlled Trial"],"prefix":"10.1159","volume":"249","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2382-1111","authenticated-orcid":false,"given":"Rodrigo","family":"Anguita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Ferro Desideri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice","family":"Roth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ines","family":"Schumacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3447-2359","authenticated-orcid":false,"given":"Martin","family":"Zinkernagel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David G.","family":"Charteris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2026,1,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2010.190314"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000003131"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2010.190306"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200412000-00007"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/1745-0179-3-10"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e31825d7ea4"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-14-358"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9394(01)01423-4"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.02.011"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000817"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114489"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.13.10.21"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000004416"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000003605"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2004.07.049"}],"container-title":["Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000550679","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T16:02:30Z","timestamp":1777305750000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000550679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,29]]},"references-count":15,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,4,27]]},"published-print":{"date-parts":[[2026,5,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000550679","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.31181608","asserted-by":"subject"}]},"ISSN":["0030-3755","1423-0267"],"issn-type":[{"value":"0030-3755","type":"print"},{"value":"1423-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,29]]}}}