{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T13:13:03Z","timestamp":1773234783419,"version":"3.50.1"},"reference-count":13,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:00:00Z","timestamp":1769212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:00:00Z","timestamp":1769212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"<jats:p>Introduction: Castleman disease (CD) is a disease characterized by chronic lymphoid reactive hyperplasia. CD transforming into angioimmunoblastic T-cell lymphoma (AITL) complicated by hemophagocytic lymphohistiocytosis (HLH) is a rare and fatal disease with rapid progression, poor treatment, and poor prognosis. Case Presentation: We present a case of idiopathic multicentric CD-transformed AITL complicated by HLH that achieved good therapeutic outcomes after treatment with ruxolitinib combined with CHOP regimen. The Epstein-Barr virus (EBV) in the peripheral blood of this patient remained positive throughout the course of the disease. Conclusion: EBV could be involved in the mechanism of CD transforming into AITL complicated with HLH. Ruxolitinib combined with CHOP regimen may be a potentially effective treatment for this disease.<\/jats:p>","DOI":"10.1159\/000550691","type":"journal-article","created":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T17:00:35Z","timestamp":1769274035000},"page":"342-348","source":"Crossref","is-referenced-by-count":0,"title":["Transformation of Castleman Disease into Angioimmunoblastic T-Cell Lymphoma Complicated by Hemophagocytic Lymphohistiocytosis: A Case Report and Literature Review"],"prefix":"10.1159","volume":"19","author":[{"given":"Guangqiang","family":"Meng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saran","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2026,1,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10022"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v99.7.2331"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1086\/374663"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-020-0990-y"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-010-0758-7"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.061026"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2024.2436037"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1177\/1066896912444926"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2018.6420"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106210"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.614704"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28631"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2024026139"}],"container-title":["Case Reports in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000550691","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T17:01:17Z","timestamp":1773162077000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000550691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,24]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000550691","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.31143784","asserted-by":"subject"}]},"ISSN":["1662-6575"],"issn-type":[{"value":"1662-6575","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,24]]}}}