{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T13:12:42Z","timestamp":1772889162882,"version":"3.50.1"},"reference-count":27,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Dermatol"],"abstract":"<jats:p>Introduction: Radiation-induced perineal ulcers are often refractory to conventional dry exposure therapies. This article reports a case of extensive radiation-induced ulceration successfully managed using a moist wound healing protocol. Case Presentation: A 67-year-old male developed progressive perianal, scrotal, and penile ulceration following radiotherapy for rectal carcinoma. Four weeks of conventional dry exposure therapy proved ineffective. Upon admission, the patient was transitioned to a holistic treatment incorporating moist wound healing. This approach resulted in complete reepithelialization of the lesions within 1 week. Conclusion: This case demonstrates the limitations of dry healing protocols for radiation-induced cutaneous injuries. The application of moist wound healing principles provided rapid efficacy. This offers a valuable clinical strategy for managing refractory perineal radiation ulcers.<\/jats:p>","DOI":"10.1159\/000550713","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T17:00:52Z","timestamp":1769706052000},"page":"115-122","source":"Crossref","is-referenced-by-count":0,"title":["Holistic Treatment Incorporating Moist Wound Healing for Postoperative Radiation-Induced Perineal Ulcer in Rectal Malignancy: A Case Report"],"prefix":"10.1159","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1277-4332","authenticated-orcid":false,"given":"Guikuan","family":"Nie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yahong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xichuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiyong","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiyang","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinping","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongmeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2026,1,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1089\/photob.2023.0152"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2018.11.055"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M500503200"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2013.08.011"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.156022"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000527037"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16584"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-24-0134"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2017-0484"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1556\/004.2020.00005"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1546"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13337"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27041276"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1329.023"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.736"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102998"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2022.02.001"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.752303"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpor.2011.02.004"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25063320"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13081002"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2024.213937"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.2001.00997.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1080\/1061186021000001814"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-023-01243-9"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2021.08.016"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-007-1560-1"}],"container-title":["Case Reports in Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000550713","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T17:00:48Z","timestamp":1772816448000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000550713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,29]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000550713","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.31185739","asserted-by":"subject"}]},"ISSN":["1662-6567"],"issn-type":[{"value":"1662-6567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,29]]}}}