{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T16:43:33Z","timestamp":1777308213774,"version":"3.51.4"},"reference-count":46,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis"],"abstract":"<jats:p>&lt;p&gt;Introduction: Enteral feeding via percutaneous endoscopic gastrostomy (PEG) is commonly used for patients requiring long-term nutritional support. However, PEG insertion carries a risk of infection, including methicillin-resistant Staphylococcus aureus (MRSA) peristomal infections. This systematic review and meta-analysis aimed to evaluate the association between MRSA colonization and the risk of PEG-related infections. Methods: A systematic search was conducted in four major databases \u2013 Embase, MEDLINE, Cochrane, and Scopus \u2013 focusing on studies reporting MRSA colonization and PEG-related infections. Data were analyzed using RevMan v5.3. Odds ratios (OR) were calculated for dichotomous outcomes using a random-effects model. Statistical significance was defined as p &lt; 0.05. Heterogeneity was assessed using the I2 statistic. Results: Five studies encompassing 286 patients were included in the meta-analysis. Among them, 77 patients were nasopharyngeal MRSA-positive, and 209 were MRSA-negative. MRSA colonization was significantly associated with an increased risk of PEG-related peristomal infection (OR: 24.31; 95% CI: 5.20\u2013113.65; p &lt; 0.0001). Moderate heterogeneity was observed among studies (I2 = 69%, p = 0.01), likely reflecting differences in study design and infection definition; however, the overall association remained statistically significant. Conclusion: Nasopharyngeal MRSA colonization is strongly associated with a higher risk of PEG-site infection. These findings highlight the importance of MRSA screening and consideration of colonization status prior to PEG tube insertion. Enhanced infection control strategies should be implemented in MRSA-positive patients to reduce the risk of complications. However, given the limited number of included studies (n = 5; 286 patients), these conclusions should be interpreted with caution. Larger, well-designed studies are needed to validate these associations and identify the most effective preventive measures for MRSA-colonized individuals undergoing PEG placement. &lt;\/p&gt;<\/jats:p>","DOI":"10.1159\/000550720","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T17:01:39Z","timestamp":1770138099000},"page":"206-215","source":"Crossref","is-referenced-by-count":0,"title":["Nasopharyngeal Methicillin-Resistant Staphylococcus aureus Carriage and Risk of Percutaneous Endoscopic Gastrostomy-Related Infection: A Systematic Review and 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