{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T18:29:44Z","timestamp":1774463384013,"version":"3.50.1"},"reference-count":6,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfus Med Hemother"],"abstract":"<jats:p>Background: Ewing sarcoma (ES) is one of the most frequent sarcomas in children and young adults. Dose-intensified induction with vincristine, doxorubicin, cyclophosphamide, ifosfamide and etoposide (VDC\/IE) proved to be more efficient than vincristine, ifosfamide, doxorubicin and etoposide (VIDE) and has emerged as a new standard. Here, we analyzed peripheral blood (pB) and stem-cell yields of adult patients after the induction with VDC\/IE and compared them with historic control after VIDE induction. Methods: Stem-cell collections of 6 adult ES patients (all male) after VDC\/IE were analyzed. Stimulation with filgrastim 5 \u00b5g\/kg bid was applied in all patients. Results: All patients underwent stem-cell collection with a single apheresis without the use of plerixafor. Collections were performed after 2 (n = 2), 3 (n = 1), and 4 (n = 3) courses of induction chemotherapy. Median CD34+ in pB (\/\u00b5L) was 176.3 compared to 68.3 in the historic cohort (p = 0.26). The median yields of CD34+, CD3+, and CD56+ (106 cells\/kg body weight) in the actual and in the historic cohorts did not differ. No difference regarding the collection efficiency nor vitality 24 h after thawing of the cryoconserved products were noticed. Conclusion: Intensification of induction does not seem to affect the feasibility of stem-cell mobilization and the collection or graft composition in adult patients with ES. Confirmation of our findings in larger cohorts is warranted.<\/jats:p>","DOI":"10.1159\/000550755","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T17:01:04Z","timestamp":1771261264000},"page":"1-4","source":"Crossref","is-referenced-by-count":0,"title":["The Induction Regimen Does Not Affect Stem-Cell Collection in Adult Patients with Ewing Sarcoma"],"prefix":"10.1159","author":[{"given":"Anne-Marie","family":"Scheuble","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Heyn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrica","family":"Bach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Pohl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlon","family":"Hu\u00dftegge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandy","family":"Br\u00fcckner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madlen","family":"Jentzsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg-Nikolaus","family":"Franke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Herling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximillian","family":"Merz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Menger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Lordick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uwe","family":"Platzbecker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3920-7490","authenticated-orcid":false,"given":"Klaus H.","family":"Metzeler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8398-285X","authenticated-orcid":false,"given":"Vladan","family":"Vu\u010dini\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2026,2,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01790-1"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2018.78.2516"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17013"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12960"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.04.106"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2018.01.007"}],"container-title":["Transfusion Medicine and Hemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000550755","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T17:00:50Z","timestamp":1774458050000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000550755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,16]]},"references-count":6,"URL":"https:\/\/doi.org\/10.1159\/000550755","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.31330231","asserted-by":"subject"}]},"ISSN":["1660-3796","1660-3818"],"issn-type":[{"value":"1660-3796","type":"print"},{"value":"1660-3818","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,16]]}}}