{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T17:53:04Z","timestamp":1774288384879,"version":"3.50.1"},"reference-count":26,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiorenal Med"],"abstract":"<jats:p>Background: The risk for contrast-induced acute kidney injury (CI-AKI) following cardiac procedures involving contrast administration is particularly high among chronic kidney disease (CKD) patients. Neutrophil gelatinase-associated lipocalin (NGAL) has been widely studied as an early marker for renal injury. However, CKD could impact NGAL levels and alter their predictive performance. This study aimed to evaluate a novel baseline \u201cindexed NGAL\u201d (I-NGAL), calculated by adjusting NGAL to the estimated glomerular filtration rate (eGFR), for the prediction of CI-AKI in CKD patients undergoing elective transcatheter aortic valve replacement (TAVR). Methods: A total of 134 CKD patients undergoing elective TAVR were included. Serum NGAL levels were drawn at hospital admission. Patients were followed for the occurrence of CI-AKI. Receiver-operator characteristic methods were used to identify optimal sensitivity and specificity for I-NGAL. Univariate and multivariate binary logistic regression models were used to assess I-NGAL predictive performance. Results: Overall, 35\/134 patients (26%) developed CI-AKI following TAVR; both NGAL and I-NGAL were significantly higher among patients having CI-AKI. I-NGAL results had a higher predictive ability than unindexed NGAL results (AUC of 0.83 vs. 0.78, p &lt; 0.001). The optimal I-NGAL cutoff for prediction of CI-AKI was 4, with a sensitivity of 71%, a specificity of 77%, and a negative predictive value of 88%. In a multivariate logistic regression model, I-NGAL was independently associated with CI-AKI (OR 1.22, 95% CI: 1.05\u20131.41; p = 0.007). I-NGAL level &gt;4 was also independently associated with CI-AKI (OR 8.13, 95% CI 3\u201321.8, p &lt; 0.001). Conclusion: Among CKD patients undergoing elective TAVR, adjusting baseline NGAL values according to eGFR yields an I-NGAL that serves as an improved tool for predicting and ruling out CI-AKI, regardless of baseline renal function.<\/jats:p>","DOI":"10.1159\/000550837","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T17:01:44Z","timestamp":1770138104000},"page":"80-86","source":"Crossref","is-referenced-by-count":0,"title":["Indexed Neutrophil Gelatinase-Associated Lipocalin: Improving Prediction and Ruling Out of Contrast-Induced Nephropathy"],"prefix":"10.1159","volume":"16","author":[{"given":"Shafik","family":"Khoury","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8882-9109","authenticated-orcid":false,"given":"Shir","family":"Frydman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moran Gvili","family":"Perlman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shmuel","family":"Banai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haytham Abu","family":"Katash","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yacov","family":"Shacham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181b9eb3b"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-014-0680-8"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11216565"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0247304"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-023-01652-6"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2013.06.016"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/01.asn.0000088027.54400.c6"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000193567.88685.f4"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.21037\/jlpm.2017.12.09"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2009.07.020"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1177\/0004563214521795"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000368474"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/MCA.0000000000001261"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000143726"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03530708"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.12181212"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjem.2017.03.002"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159\/000492407"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcha.2020.100695"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.04.035"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.030759"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22817"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.2229"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.6091\/ibj.1380.2015"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00448.2010"}],"container-title":["Cardiorenal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000550837","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T17:01:09Z","timestamp":1774285269000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000550837"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,3]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000550837","archive":["Portico"],"relation":{},"ISSN":["1664-3828","1664-5502"],"issn-type":[{"value":"1664-3828","type":"print"},{"value":"1664-5502","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,3]]}}}