{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T17:53:26Z","timestamp":1774288406413,"version":"3.50.1"},"reference-count":16,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Neurol"],"abstract":"<jats:p>Background: Generalized myasthenia gravis (gMG) is an autoimmune disease associated with several autoantibodies that attack neuromuscular junctions. Parenteral fast-acting treatment (FT) using steroid pulses, intravenous immunoglobulin (IVIg) and\/or plasmapheresis is beneficial for the initial treatment of gMG. However, some patients with gMG have concomitant cardiovascular diseases, such as cardiac insufficiency and ischemic heart disease, in real-world clinical practice. Thus, conventional FT is sometimes difficult to administer in these patients because of its potential cardiovascular side effects. Case Presentation: We report a case of a patient with gMG complicated by cardiovascular disease who was successfully treated with a new therapy using the neonatal Fc receptor inhibitor efgartigimod instead of conventional early FT with steroid pulses, IVIg, and\/or plasmapheresis. Conclusion: Efgartigimod may represent a feasible alternative to conventional FT for the management of gMG, particularly in patients with significant cardiovascular comorbidities.<\/jats:p>","DOI":"10.1159\/000550908","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T14:50:51Z","timestamp":1770648651000},"page":"146-153","source":"Crossref","is-referenced-by-count":0,"title":["Usefulness of Early Treatment with Efgartigimod in Patients with Generalized Myasthenia Gravis Complicated by Cardiovascular Disease: A Case Report"],"prefix":"10.1159","volume":"18","author":[{"given":"Rie","family":"Kawakita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazushi","family":"Deguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2026,2,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70063-8"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1602678"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25397"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s42399-023-01539-4"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1G104"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003432"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000529110"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-023-01000-z"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.363824"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb11015.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.52.7.1487"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00159-9"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-024-12293-5"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10472"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000203722"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2025.1673297"}],"container-title":["Case Reports in Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000550908","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T17:01:14Z","timestamp":1774285274000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000550908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,9]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000550908","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.31281730","asserted-by":"subject"}]},"ISSN":["1662-680X"],"issn-type":[{"value":"1662-680X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,9]]}}}