{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T16:58:55Z","timestamp":1780937935692,"version":"3.54.1"},"reference-count":10,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Blood Purif"],"abstract":"<jats:p>Introduction: The Seraph-100 Microbind Affinity Blood Filter is a novel therapy for extracorporeal blood-borne pathogen removal. To guarantee adequate therapy, the Seraph-100 relies on specific blood flows over a set treatment time which is achieved by providing Seraph-100 through a dialysis machine. Septic patients on extracorporeal membrane oxygenation (ECMO) support but not on renal replacement have received Seraph-100 therapy through the ECMO circuit with the ECMO pump driving flows. However, there are limited data to prove that this strategy, which avoids the use of a dialysis machine, achieves therapeutic flow rates through the Seraph-100 filter. Methods: Our experiment involving swine models was conducted in detail with a configuration to connect the Seraph-100 circuit to the ECMO circuit and have blood flow through the filter in parallel with the patient. Seraph-100 flows were recorded at incremental changes in ECMO blood flow between 1.5 L\/min and 5 L\/min. Results: With flows as low as 1.5 L\/min, Seraph-100 flows averaged 137.27 mL\/min (95% PI: 88\u2013223 mL\/min). When ECMO flow was 5 L\/min, Seraph-100 flows averaged 356.50 mL\/min (95% PI: 272\u2013536 mL\/min). Adding the Seraph-100 circuit caused ECMO revolutions per minute (RPMs) to increase by 31.2 (p &lt; 0.05) and venous pressures to drop by \u22123.47 mm Hg (p &lt; 0.05) to maintain the same ECMO blood flow. Conclusion: Connecting a Seraph-100 filter directly to an ECMO circuit and having Seraph-100 blood flow driven by the ECMO pump is feasible. This configuration achieves adequate flows for clinical therapy and has minimal changes in ECMO dynamics.<\/jats:p>","DOI":"10.1159\/000550914","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T14:49:39Z","timestamp":1770648579000},"page":"268-273","source":"Crossref","is-referenced-by-count":0,"title":["Seraph-100 Microbind Affinity Blood Filter Flow Driven by the Extracorporeal Membrane Oxygenation Circuit in Extracorporeal Membrane Oxygenation Patients"],"prefix":"10.1159","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9651-4553","authenticated-orcid":false,"given":"Jason M.","family":"Thomas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas E.","family":"Villalobos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James K.","family":"Aden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn A.","family":"Negaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terence P.","family":"Lonergan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,2,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2016.11.006"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-021-03597-3"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000508647"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/milmed\/usad063"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/CCE.0000000000000662"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/CCE.0000000000000180"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pmbts.2019.02.002"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-024-02818-w"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/jbcr\/irac012.263"}],"container-title":["Blood Purification"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000550914","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T16:04:38Z","timestamp":1780934678000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000550914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,9]]},"references-count":10,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,6,8]]},"published-print":{"date-parts":[[2026,6,10]]}},"URL":"https:\/\/doi.org\/10.1159\/000550914","archive":["Portico"],"relation":{},"ISSN":["0253-5068","1421-9735"],"issn-type":[{"value":"0253-5068","type":"print"},{"value":"1421-9735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,9]]}}}