{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T16:37:51Z","timestamp":1777912671515,"version":"3.51.4"},"reference-count":18,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"abstract":"<jats:p>Introduction: The aim of this study was to evaluate the pressure-control performance and irrigation efficiency of an upgraded vacuum-assisted ureteroscopic system (VA-URS) compared with traditional ureteroscopy (T-URS) using an in vitro kidney model. Methods: An artificial renal pelvis model was used to simulate ureteroscopy under varying irrigation pressures (50, 100, 150 cmH&lt;sub&gt;2&lt;\/sub&gt;O) and flow rates (30\u201350 mL\/min). Intrapelvic pressure and effective irrigation flow rates were continuously recorded. Three-way ANOVA assessed the influence of surgical method, irrigation pressure, and flow rate, while multiple regression models quantified pressure-parameter relationships. Results: VA-URS consistently produced lower intrapelvic pressures than T-URS across all settings. At 50 cmH&lt;sub&gt;2&lt;\/sub&gt;O with 30 mL\/min, pressures were \u221221.47 \u00b1 1.86 cmH&lt;sub&gt;2&lt;\/sub&gt;O versus 24.73 \u00b1 1.56 cmH&lt;sub&gt;2&lt;\/sub&gt;O (p &lt; 0.01). At 150 cmH&lt;sub&gt;2&lt;\/sub&gt;O with 50 mL\/min, values were 50.13 \u00b1 2.14 cmH&lt;sub&gt;2&lt;\/sub&gt;O versus 61.53 \u00b1 1.27 cmH&lt;sub&gt;2&lt;\/sub&gt;O (p &lt; 0.01). Effective irrigation flow was also higher with VA-URS (24.50 \u00b1 0.79 vs. 20.40 \u00b1 0.70 mL\/min at 50 cmH&lt;sub&gt;2&lt;\/sub&gt;O\/30 mL\/min; p &lt; 0.01). Regression modeling demonstrated strong predictive accuracy (R2 = 0.984 for VA-URS) and distinct pressure-flow dynamics compared with T-URS. Conclusions: The upgraded VA-URS system significantly enhances intrapelvic pressure management and irrigation efficiency compared with T-URS in this in vitro model. These bench findings support further translational evaluation; however, animal and clinical studies are required to confirm clinical benefit and safety.<\/jats:p>","DOI":"10.1159\/000550986","type":"journal-article","created":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T17:01:15Z","timestamp":1772730075000},"page":"1-8","source":"Crossref","is-referenced-by-count":0,"title":["Enhanced Pressure Management Using an Upgraded Vacuum-Assisted Ureteroscopic System: Experimental Validation and Predictive Modeling"],"prefix":"10.1159","author":[{"given":"Ying-Tong","family":"Zuo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1362-1937","authenticated-orcid":false,"given":"Bo-Lun","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong-Zu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong-Hua","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2026,3,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-024-01647-w"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-019-03012-1"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-018-2378-4"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2025.02.010"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/bju.16539"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2007.09.039"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-021-00917-1"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000001345"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-023-04654-y"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajur.2024.01.008"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1089\/end.2006.20.179"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.12.023"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000507266"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-022-04075-3"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2023.12.031"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2024.02.007"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000002202"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00240-023-01462-2"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000550986","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:01:06Z","timestamp":1777651266000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000550986"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,5]]},"references-count":18,"URL":"https:\/\/doi.org\/10.1159\/000550986","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,5]]}}}