{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:17:50Z","timestamp":1783012670098,"version":"3.54.6"},"reference-count":66,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncol Res Treat"],"abstract":"<jats:p>The ESMO Congress 2025 in Berlin marked a milestone in precision oncology with the introduction of the first dedicated tumor-agnostic track, reflecting the shift from organ-based to molecularly defined cancer therapy. Across multiple sessions, updated data on biomarker-driven and pathway-based treatments demonstrated how targeted therapies can transcend histologic boundaries. Highlights included long-term results for approved tumor-agnostic agents (e.g., NTRK and BRAF-directed therapies, HER2-targeted antibody-drug conjugates [ADCs], as well as next-generation KRAS inhibitors, HER2- and TROP2-directed tyrosine kinase inhibitors and ADCs, and novel targets such as MTAP deletions, MET amplification, CD44v9 and MUC1. In parallel, advances in synthetic-lethality strategies beyond PARP inhibition and the clinical implementation of ctDNA-based minimal-residual-disease monitoring showcased how molecular profiling and liquid biopsies are reshaping treatment selection and response assessment. Taken together, these developments highlight the growing momentum in biomarker-guided and molecularly driven cancer care.<\/jats:p>","DOI":"10.1159\/000551042","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T17:00:56Z","timestamp":1771520456000},"page":"330-340","source":"Crossref","is-referenced-by-count":0,"title":["Moving Tumor-Agnostic Therapy to the Big Stage: Translational and Molecular Oncology Highlights from the ESMO Congress 2025"],"prefix":"10.1159","volume":"49","author":[{"given":"Elisabeth","family":"Tregel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damian T.","family":"Rieke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalen","family":"Bleckmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5310-3754","authenticated-orcid":false,"given":"Christoph Benedikt","family":"Westphalen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ina","family":"Pretzell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Lange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Quante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linus D.","family":"Kloker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,2,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-024-00216-3"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(25)00322-5"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1709968"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-57941-0"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.02105"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.41165"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30445-9"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1714448"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30691-6"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2023.09.2405"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(22)00541-1"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01931-y"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.00762"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.02005"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2024.07.730"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1200\/PO.18.00183"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2025.08.2637"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2025.08.605"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2025.08.1538"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16061215"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2025.08.2628"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2025.08.3601"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2021.843"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-15-0375"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2025.08.2473"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2025.08.1526"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2503704"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2511065"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.7150\/jca.57711"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-025-03638-2"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1612674"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.21037\/apm-20-105"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.10613"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2023.10.117"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1200\/JCO-24-01269"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2512071"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26213-y"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1038\/s41698-022-00334-z"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2025.08.1495"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2303810"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2025.08.1483"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2025.08.2470"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2024.42.16_suppl.3007"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2204619"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00221-0"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2025.08.1484"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2025.08.1485"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2025.43.4_suppl.722"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2025.43.4_suppl.724"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.am2025-ct019"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2025.09.110"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2025.08.2145"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1010337"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2025.104535"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2024.08.2339"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2025.08.1572"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2025.08.2648"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2025.08.1487"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2025.08.1491"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2025.08.1490"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2025.08.1486"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2025.08.1492"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2025.08.1493"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2025.08.1494"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2511885"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-025-04030-w"}],"container-title":["Oncology Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000551042","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T16:30:16Z","timestamp":1783009816000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000551042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,19]]},"references-count":66,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,7,2]]},"published-print":{"date-parts":[[2026,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000551042","archive":["Portico"],"relation":{},"ISSN":["2296-5270","2296-5262"],"issn-type":[{"value":"2296-5270","type":"print"},{"value":"2296-5262","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,19]]}}}