{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T16:14:15Z","timestamp":1778256855705,"version":"3.51.4"},"reference-count":26,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"abstract":"<jats:p>Introduction: Primary head and neck mucosa-associated lymphoid tissue lymphoma (HN-MALT) is a rare B-cell lymphoma whose epidemiology, clinical features, and treatment strategies remain unclear. Methods: We conducted a retrospective analysis of HN-MALT data from the Surveillance, Epidemiology, and End Results (SEER) database (2000\u20132021) and compared the incidence and mortality rates among age groups. The Kaplan-Meier was used to determine the overall survival (OS) and lymphoma-specific survival (LSS). Prognostic factors were identified using univariate and multivariate Cox regression models. Results: In a cohort of 2,517 patients, the annual incidence rate of HN-MALT in patients \u226560 years old was higher than that in those &lt;60 years old, with an increasing trend in overall mortality over time. Multivariable Cox analysis identified that male, age \u226560 years, being divorced\/separated\/widowed, and having a second malignant neoplasm (SMN) were associated with poorer OS and LSS. Additionally, not receiving radiotherapy was identified as a risk factor for poorer OS, whereas not undergoing surgical treatment was associated with decreased LSS. Notably, subgroup analyses demonstrated that the combination of surgery and radiotherapy consistently yielded superior survival outcomes across key patient strata. It significantly improved OS compared to radiotherapy alone in males, females, patients aged \u226560, and married patients, regardless of SMN status. Most strikingly, this combined modality led to a pronounced improvement in LSS, particularly among patients aged \u226560 (males: hazard ratio [HR] = 0.221; females: HR = 0.447) and those categorized by marital status (married: HR = 0.379; divorced\/separated\/widowed: HR = 0.338), as well as in patients with or without SMN. The Kaplan-Meier analyses confirmed that surgery combined with radiotherapy improved OS and LSS compared to radiotherapy alone in certain subgroups of patients with HN-MALT. Conclusion: HN-MALT has unique clinical and pathological characteristics; surgery combined with radiotherapy can improve OS and LSS.<\/jats:p>","DOI":"10.1159\/000551044","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T17:01:26Z","timestamp":1773162086000},"page":"1-14","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Surgical Intervention on the Survival of Primary Head and Neck MALT Lymphoma"],"prefix":"10.1159","author":[{"given":"Jianhong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21330"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2102568"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25446"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022007772"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2024.1342913"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2017.01.001"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2024.102592"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.19064"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-03-771915"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29231"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1177\/01945998211041533"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2007.11.011"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2015.1061700"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1327309"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26103"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2147\/cmar.S133291"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.Ccr-21-1704"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(16)32407-2"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-024-05647-z"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000028492"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2023.0057"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2022-158631"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717x-8-2"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2022.05.034"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt343"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-12-624304"}],"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000551044","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T16:01:13Z","timestamp":1778256073000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000551044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,10]]},"references-count":26,"URL":"https:\/\/doi.org\/10.1159\/000551044","archive":["Portico"],"relation":{},"ISSN":["0030-2414","1423-0232"],"issn-type":[{"value":"0030-2414","type":"print"},{"value":"1423-0232","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,10]]}}}