{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T16:58:31Z","timestamp":1780937911826,"version":"3.54.1"},"reference-count":31,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologica"],"abstract":"<jats:p>Introduction: The aim of this study was to compare the emulsification rates, intraocular pressure (IOP) changes, and retinal hyperreflective foci (HRF) between low-viscosity (1,000 cS) and high-viscosity (5,000 cS) silicone oils (SOs) used as tamponade agents following 25-gauge pars plana vitrectomy (PPV) in cases of na\u00efve macula-off rhegmatogenous retinal detachment using an artificial intelligence (AI)-based quantification approach. Methods: This retrospective study was conducted in eyes treated with PPV and SO tamponade. The clinical parameters that were assessed included best-corrected visual acuity (BCVA), IOP, the presence of emulsification in the iridocorneal angle \u2013 in the anterior or posterior chambers, and structural retinal biomarkers such as intraretinal fluid, subretinal fluid, and HRF detected and quantified through an AI-based analysis of spectral-domain optical coherence tomography (OCT) images. Results: Twenty-five eyes were enrolled (12 with 1,000-cS SO and 13 with 5,000-cS SO endotamponades) for this study. No statistically significant differences in BCVA or anatomical outcomes between the two groups were found. However, SO emulsification occurred more often in the 1,000-cS group (66%) compared to the 5,000-cS group (7%) (p = 0.0036). Elevated IOP was more frequent in the 1,000-cS group (8 vs. 4 cases; p = 0.03), and HRF count was significantly higher in eyes with 1,000-cS oil (p = 0.04). Conclusion: High-viscosity SO demonstrated a lower emulsification rate and reduced inflammatory response compared to low-viscosity SO, with no compromise in visual outcomes. AI-assisted OCT analysis enabled an accurate, automated detection of HRF, supporting its utility in monitoring SO-related complications.<\/jats:p>","DOI":"10.1159\/000551074","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T17:00:56Z","timestamp":1772125256000},"page":"230-237","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Evaluation of High- versus Low-Viscosity Silicone Oil in Macula-Off Retinal Detachment: Emulsification, Inflammation, and AI-Assisted Biomarker 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