{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T16:51:07Z","timestamp":1776703867121,"version":"3.51.2"},"reference-count":11,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Ophthalmol"],"abstract":"<jats:p>Introduction: Hyaluronic acid (HA) fillers are widely utilized in esthetic medicine for facial rejuvenation, including in the periocular region. Although generally considered safe, severe inflammatory responses can occur. This report describes a case of a 42-year-old woman who developed a significant periocular reaction following HA microinjections, clinically resembling necrotizing fasciitis. Case Presentation: The patient, with no significant medical or ophthalmic history, presented to the emergency department with acute periocular swelling, redness, and an inability to open her right eye 3 h after HA microinjections. Clinical examination revealed marked periorbital edema, chemosis, and restricted ocular motility in the right eye. The severity of the presentation initially suggested necrotizing fasciitis. A CT scan indicated preseptal cellulitis without post-septal involvement. Treatment with intravenous antibiotics, systemic corticosteroids, antihistamines, and topical therapies led to significant improvement. Conclusion: This case highlights the need to recognize severe inflammatory reactions following periocular HA injections, which may mimic life-threatening conditions. Timely intervention and systematic evaluation are essential for achieving favorable outcomes.<\/jats:p>","DOI":"10.1159\/000551132","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T17:00:49Z","timestamp":1772125249000},"page":"357-364","source":"Crossref","is-referenced-by-count":0,"title":["Severe Periocular Inflammatory Reaction Mimicking Necrotizing Fasciitis following Hyaluronic Acid Microinjections: A Case Report and Literature Review"],"prefix":"10.1159","volume":"17","author":[{"given":"Tehila","family":"Shlomov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nir","family":"Erdinest","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yossi","family":"Eshel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zvi","family":"Gur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2022.2099899"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2000.99202.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093\/asjof\/ojae052"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-024-01202-3"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjad028"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2007.00331.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-021-02730-5"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1055\/a-2184-6554"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000595"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2005.31166"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.legalmed.2021.101989"}],"container-title":["Case Reports in Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000551132","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T16:01:04Z","timestamp":1776700864000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000551132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,26]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000551132","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.31420445","asserted-by":"subject"}]},"ISSN":["1663-2699"],"issn-type":[{"value":"1663-2699","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,26]]}}}