{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T16:51:12Z","timestamp":1776703872776,"version":"3.51.2"},"reference-count":30,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"abstract":"<jats:p>Introduction: The aim of this study was to assess the short-term clinical effects of individualized, hardware-assisted airway clearance techniques (ACTs) during acute non-cystic fibrosis bronchiectasis (NCFB exacerbations). Methods: In this prospective, controlled cohort study, 46 adults hospitalized with computed tomography-confirmed bilateral (CT-confirmed bilateral) NCFB were assigned to an intervention group (ACT plus pharmacological therapy; n = 23) or a control group (pharmacological therapy alone; n = 23). ACT modality (intrapulmonary percussive ventilation [IPV], high-frequency chest wall oscillation, or mechanical insufflation-exsufflation) was selected based on IPV tolerability and respiratory muscle strength maximum inspiratory pressure Z-score. Outcomes included 24-hour sputum volume, dyspnea (modified medical research council dyspnea scale [mMRC], Borg), spirometry, inflammatory markers, and length of hospital stay. Results: Compared with controls, the intervention group showed greater reductions in sputum volume (\u221215 vs. \u221210 mL; p = 0.005) and dyspnea (mMRC \u22121.0 vs. 0.0; Borg \u22122.0 vs. \u22121.0; all p &lt; 0.05), as well as a shorter hospital stay (median 7 vs. 9 days; p &lt; 0.05). There were no differences between groups in spirometric or inflammatory outcomes, and no serious adverse events occurred. Conclusions: Individualized, physiology-guided device-based ACTs improved mucus clearance and dyspnea during acute NCFB exacerbations and were well tolerated, without short-term spirometric change. Larger studies with longer follow-up are needed to confirm efficacy before routine clinical implementation.<\/jats:p>","DOI":"10.1159\/000551195","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T17:01:03Z","timestamp":1771866063000},"page":"1-11","source":"Crossref","is-referenced-by-count":0,"title":["Physiology-Guided Selection of Hardware-Assisted Airway Clearance Techniques during Acute Exacerbations of Non-Cystic Fibrosis Bronchiectasis"],"prefix":"10.1159","author":[{"given":"Aizhan","family":"Aminova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Latypova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexey","family":"Pak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantin","family":"Garkalov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulnara","family":"Kamalbekova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1177\/1479972314562407"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pulmoe.2018.06.006"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s41030-024-00275-x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.37275\/bsm.v9i4.1255"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011231.pub2"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.21037\/jtd-2024-2106"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.2680"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.23736\/S0031-0808.20.03735-0"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02053-2022"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2023.06.040"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.09263"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001401.pub4"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S396317"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0086-2016"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-91692-8"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0085-2024"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011699.pub2"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.01098"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6174936"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0161-2019"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S378642"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00518-2024"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.4046\/trd.2023.0010"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2020.06.050"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.06882"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.56792\/IJIH3243"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1177\/1479972310375595"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008351.pub3"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1007\/s41669-021-00299-y"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000551195","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T16:01:08Z","timestamp":1776700868000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000551195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,23]]},"references-count":30,"URL":"https:\/\/doi.org\/10.1159\/000551195","archive":["Portico"],"relation":{},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"value":"1011-7571","type":"print"},{"value":"1423-0151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,23]]}}}