{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T16:44:04Z","timestamp":1777049044432,"version":"3.51.4"},"reference-count":24,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["GE Port J Gastroenterol"],"abstract":"<jats:p>Aims: The aim of the study was to evaluate the impact of type 2 diabetes on hepatic fibrosis in patients with MASLD. Materials and Methods: This cross-sectional study used retrospective data from patients with MASLD who underwent liver elastography between July 2022 and February 2024. Controlled attenuation parameter \u2265248 dB\/m was considered diagnostic for steatosis; elasticity (kPa) of 8.7\u201310.2 kPa for F3, and &gt;10.2 kPa for F4. Clinical, demographic, and laboratory data were collected. Other etiologies of liver disease were excluded. Patients were divided into group 1 (with diabetes) and group 2 (without diabetes). Results: A total of 252 individuals were included, 96 in group 1 and 156 in group 2. The mean age was 56 years, and the median body mass index was 31.0 kg\/m2. There was a positive correlation between the degree of steatosis and the stage of fibrosis (p &lt; 0.01). The prevalence of steatosis S3 was 83.3% in group 1 versus 70.5% in group 2 (p = 0.022). Fibrosis F3\/F4 was present in 45.8% of group 1 compared to 12.2% of group 2 (p &lt; 0.001), while presumed cirrhosis affected 33.3% of group 1 and 6.4% of group 2 (p &lt; 0.001). Conclusions: Type 2 diabetes was associated with a higher degree of steatosis and more severe hepatic fibrosis in patients with MASLD, with presumed cirrhosis present in about one-third of patients with diabetes. Early diagnosis of MASLD in type 2 diabetes and screening for complications (cirrhosis and hepatocellular carcinoma) should be implemented.<\/jats:p>","DOI":"10.1159\/000551207","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T17:01:05Z","timestamp":1772470865000},"page":"413-421","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Type 2 Diabetes Mellitus on Hepatic Fibrosis in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease: A Cross-Sectional Study"],"prefix":"10.1159","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9867-4526","authenticated-orcid":false,"given":"Paula","family":"Mesquita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiane","family":"Macedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Matos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Henriques","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2455-8781","authenticated-orcid":false,"given":"Armando","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ad\u00e9lia","family":"Sim\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/hep.0000000000000520"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3390\/biom15070990"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3390\/nu7064995"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28394"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0188321"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2016160042"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13235"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.06.021"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28431"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14976"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50229"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.11.034"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-1997"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12112542"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-024-06087-7"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.04.038"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-023-01013-0"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.21918.1"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-1778"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.aohep.2021.100336"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3390\/life14020272"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2023.0350"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.aohep.2018.09.003"}],"container-title":["GE - Portuguese Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000551207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T16:00:59Z","timestamp":1777046459000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000551207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,2]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000551207","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.31436164","asserted-by":"subject"}]},"ISSN":["2341-4545","2387-1954"],"issn-type":[{"value":"2341-4545","type":"print"},{"value":"2387-1954","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,2]]}}}