{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:50:26Z","timestamp":1792083026796,"version":"4.4.0"},"reference-count":8,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Dermatol"],"abstract":"<jats:p>Introduction: Pagetoid reticulosis (PR) is a rare variant of mycosis fungoides, characterized by localized patches or plaques mainly on the distal extremities with intraepidermal proliferation of neoplastic T cells. Typically, PR exhibits a CD4-positive, CD8-negative immunophenotype, whereas a CD4\u2013\/CD8\u2013 double-negative profile is distinctly uncommon, yet in localized pagetoid reticulosis it may be associated with an indolent clinical course and favorable therapeutic response. Case Presentation: In this report, we present a case of a healthy 58-year-old male with a 3-year history of a persistent erythematous plaque on the left forearm. Histopathological analysis demonstrated atypical lymphocytes with prominent epidermotropism. Immunohistochemical staining showed double-negative CD4\/CD8 phenotype with positive CD3, CD5, and CD7. The lesion responded completely to topical therapy followed by localized radiotherapy, with clinical remission at follow-up. Conclusion: The CD4\u2212\/CD8\u2212 immunophenotype in localized pagetoid reticulosis is rare but may still be associated with an indolent clinical course and favorable therapeutic response.<\/jats:p>","DOI":"10.1159\/000551216","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:24:49Z","timestamp":1786724689000},"page":"750-755","source":"Crossref","is-referenced-by-count":0,"title":["Pagetoid Reticulosis with Double-Negative CD4\/CD8: A Rare Case Report"],"prefix":"10.1159","volume":"18","author":[{"given":"Hadeel","family":"Alsulimani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2672-4202","authenticated-orcid":false,"given":"Hamza","family":"Fadel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"Alomari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hosam","family":"Alardati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghassan","family":"Niaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-11-881268"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.16224"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2009.01323.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200202000-00009"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.01.020"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.04.018"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198801213180307"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1177\/030089160809400521"}],"container-title":["Case Reports in Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000551216","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:01:20Z","timestamp":1792080080000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000551216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,14]]},"references-count":8,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000551216","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.33255855","asserted-by":"subject"}]},"ISSN":["1662-6567"],"issn-type":[{"value":"1662-6567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,14]]}}}