{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T16:41:44Z","timestamp":1787676104522,"version":"build-2784847793"},"reference-count":33,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"abstract":"<jats:p>Introduction: Renal injury is a significant complication in ST-segment elevation myocardial infarction (STEMI) and is associated with poor outcomes. The recently introduced term acute kidney disease (AKD) describes persistent renal dysfunction lasting 7\u201390 days post-acute kidney injury (AKI). Neutrophil gelatinase-associated lipocalin (NGAL), a biomarker for tubular injury, has shown promise in predicting AKI. This study aimed to evaluate NGAL\u2019s diagnostic utility for predicting AKD in STEMI patients. Methods: This prospective observational study included 312 patients admitted with STEMI. NGAL levels were measured within 2 h of admission. AKI and AKD were defined using KDIGO criteria, and patients with chronic inflammation or end-stage renal disease were excluded. Receiver operating characteristic (ROC) analysis was performed to evaluate NGAL\u2019s predictive value for AKD and its optimal value for prediction. Results: Overall, 64 patients developed AKI (21%), with 30 (47%) progressing to AKD. Patients with AKD had higher admission NGAL levels (median 165 ng\/mL) compared to those with resolved AKI (112 ng\/mL) or no AKI (88 ng\/mL, p &lt; 0.001). NGAL had a good predictive ability for AKD (area under the ROC of 0.784), with a threshold of &gt;150 ng\/mL having 65% sensitivity and 77% specificity for correct prediction. Multivariate analysis confirmed NGAL &gt;150 ng\/mL as an independent predictor of AKD (HR 6.4, 95% CI 1.94\u201321.06, p &lt; 0.001)). Conclusion: Elevated NGAL levels are independently associated with AKD development in STEMI patients. These findings suggest NGAL could be a valuable biomarker for early risk stratification, supporting timely interventions to mitigate persistent renal injury. Further research is warranted to confirm its clinical utility.<\/jats:p>","DOI":"10.1159\/000551273","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T17:01:08Z","timestamp":1772211668000},"page":"209-217","source":"Crossref","is-referenced-by-count":1,"title":["Neutrophil Gelatinase\u2010Associated Lipocalin for the Assessment of Persistent Renal Dysfunction after Acute Kidney 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