{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T07:07:37Z","timestamp":1784358457870,"version":"3.55.0"},"reference-count":23,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Vasc Res"],"abstract":"<p>Introduction: Angiotensin converting enzyme (ACE) regulates blood pressure via the renin-angiotensin and bradykinin systems. Though synthetic ACE inhibitors are more effective, they pose several side effects. Methyl palmitate (MP), a natural fatty acid methyl ester with cytoprotective, antioxidant, anti-inflammatory, and vasodilatory properties, is not explored for its ACE inhibitory or antihypertensive potential. This study aimed to investigate the in vitro ACE inhibition of MP and its effect on L-NG-Nitro Arginine Methyl Ester (<sc>L<\/sc>-NAME)-induced hypertensive male Wistar rats. Methods: An in vitro ACE inhibition assay was conducted to compare the inhibition potency of MP with that of lisinopril. Male Wistar rats (n = 35, 7 per group) were grouped into control, disease control, and treatment groups receiving 100, 150, or 200 mg\/kg\/day of MP for 21 days each. Blood pressure, serum ACE activity, malondialdehyde (MDA), and nitric oxide (NO) levels in kidney tissue homogenate, and thoracic aorta histopathology were assessed. Results: MP inhibited ACE by 61.05% at 5 \u00b5<sc>m<\/sc>, exceeding lisinopril\u2019s 41.67%. High-dose MP significantly reduced serum ACE and MDA levels, while increasing NO (p < 0.001). Histopathology revealed near-normal vasculature, although changes in blood pressure were not statistically significant (p > 0.05). Conclusion: MP demonstrates strong natural ACE inhibition, antioxidant, and vascular protective effects, supporting further research for therapeutic optimization. <\/p><\/jats:p>","DOI":"10.1159\/000551278","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T17:01:25Z","timestamp":1773075685000},"page":"231-243","source":"Crossref","is-referenced-by-count":1,"title":["Methyl Palmitate, a Potent Angiotensin Converting Enzyme Inhibitor, Attenuates Vascular Remodeling in L-N\n G<\/sup>\n -Nitro Arginine Methyl Ester-Induced Hypertensive Wistar Rat Models"],"prefix":"10.1159","volume":"63","author":[{"given":"Ashwini","family":"Rao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padmanabha","family":"Udupa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"Rhea Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geethika","family":"Yelleti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.22159\/ajpcr.2016.v9i5.13424"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.4314\/tjpr.v16i8.19"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000100391"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1186\/s43094-020-00044-y"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2012.07.020"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.21608\/aps.2020.2003.1026"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-016-3233-1"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2011.04.016"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00583"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-5132"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000529916"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2012.684064"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-13-27"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1080\/10641963.2020.1739699"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.vascn.2019.106601"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.61186\/rbmb.13.4.495"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(78)90081-5"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(79)90738-3"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/s1734-1140(12)70846-0"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2018.10.023"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2013.04.007"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3678469"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1080\/10496475.2023.2184897"}],"container-title":["Journal of Vascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000551278","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T16:01:19Z","timestamp":1784217679000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000551278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,9]]},"references-count":23,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,7,16]]},"published-print":{"date-parts":[[2026,8,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000551278","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.31570609","asserted-by":"subject"}]},"ISSN":["1018-1172","1423-0135"],"issn-type":[{"value":"1018-1172","type":"print"},{"value":"1423-0135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,9]]}}}