{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:12:05Z","timestamp":1790014325418,"version":"4.0.1"},"reference-count":35,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebrovasc Dis Extra"],"abstract":"<jats:p>Purpose: This study aimed to explore the relationship between serum inflammatory biomarkers and the carotid atherosclerotic plaque characteristics, given prior evidence suggesting a key role of inflammation in the development of atherosclerosis. Methods: In this prospective study, patients with carotid atherosclerotic plaque were recruited. Serum high-sensitivity CRP (Hs-CRP), homocysteine (Hcy) concentrations, and neutrophil-to-lymphocyte ratio (NLR) were obtained for all enrolled patients. Carotid atherosclerosis characteristics (such as intraplaque hemorrhage [IPH] and lipid-rich necrotic core [LRNC]) were determined by three-dimensional high-resolution vessel wall imaging. The associations between Hs-CRP, Hcy, NLR, and plaque characteristics were assessed. Results: In total, 128 patients (84.4% men; mean age, 58.0 \u00b1 8.7 years) were included. Multivariate logistic regression indicated that increased Hs-CRP levels were associated with the presence of LRNC (OR = 1.23, 95% CI: 1.07\u20131.40, p = 0.003) and IPH (OR = 1.26, 95% CI: 1.10\u20131.45, p = 0.001). Multivariate linear regression confirmed a significant correlation between Hs-CRP level (\u03b2 = 3.24, 95% CI: 0.66\u20135.81, p = 0.014) and the IPH volume. For plaque burden, higher Hs-CRP levels were associated with larger max normalized wall index (NWI) (\u03b2 = 0.01, 95% CI: 0.00\u20130.02, p = 0.005) and larger Max wall thickness (\u03b2 = 0.08, 95% CI: 0.02\u20130.14, p = 0.006). NLR and Hcy levels did not show significant associations with the carotid plaque characteristics. Conclusions: Elevated Hs-CRP levels were found to be closely associated with plaque burden and vulnerable plaque characteristics. The relationship between the elevated Hs-CRP and plaque vulnerability highlights its potential role in risk stratification and early intervention strategies. Further validation in larger, multicenter population studies is required to confirm these associations.<\/jats:p>","DOI":"10.1159\/000551280","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T16:00:45Z","timestamp":1776355245000},"page":"133-140","source":"Crossref","is-referenced-by-count":1,"title":["The Correlation between Inflammatory Markers and Carotid Atherosclerotic Plaque 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