{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T16:51:33Z","timestamp":1776271893779,"version":"3.50.1"},"reference-count":21,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"abstract":"<jats:p>Introduction: The aim of this study was to assess the longitudinal intrathoracic changes after pleuroamniotic shunting (PAS) in fetuses with massive unilateral or bilateral hydrothorax. Methods: The presence of intrafetal fluid effusions and the observed\/expected lung-to-head ratio (O\/E-LHR) of both lungs were weekly evaluated in a cohort of fetuses with severe hydrothorax treated PAS in a single reference center in Mexico. Severe fetal hydrothorax was diagnosed as an accumulation of fluid within the fetal pleural space accompanied with severe bilateral lung compression, mediastinal shift, polyhydramnios, and\/or hydrops. The longitudinal changes in intrafetal fluid effusions, and pulmonary growth were analyzed by survival and multilevel analysis against weeks after fetal intervention. Results: Fifty-six pregnancies with severe fetal hydrothorax were treated with PAS at a median gestational age of 30.1 (range, 20.8\u201336.1) weeks. After shunting, all cases were longitudinally analyzed and in whom a total of 332 scans were performed (median 6, range 2\u201316). A complete disappearance of hydrops and hydrothorax was observed at a median interval of 1.6 and 5.9 weeks after PAS, respectively. A progressive increase in lung growth was observed, becoming normal O\/E-LHR at on average 7.0 weeks after PAS. Conclusion: Fetal PAS promotes disappearance of all fetal fluid effusions and a normalization of the pulmonary growth after fetal intervention.<\/jats:p>","DOI":"10.1159\/000551305","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T17:01:20Z","timestamp":1772211680000},"page":"1-7","source":"Crossref","is-referenced-by-count":0,"title":["Intrafetal Fluid Effusions and Pulmonary Growth after Pleuroamniotic Shunt in Fetuses with Severe Hydrothorax"],"prefix":"10.1159","author":[{"given":"Fredal","family":"S\u00e1nchez-Mart\u00ednez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Pel\u00e1ez-Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramiro","family":"Rojas-Pillaca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9638-5950","authenticated-orcid":false,"given":"Rosa","family":"Villalobos-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6019-938X","authenticated-orcid":false,"given":"Saulo","family":"Molina-Giraldo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5999-866X","authenticated-orcid":false,"given":"Rogelio","family":"Cruz-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3468(89)80509-3"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2017.03.005"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/01.gim.0000170774.86075.12"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2726"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000020863"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1808"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7507"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/pd.3840"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4989"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/uog.4052"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5458"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6070"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000514912"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198810273191706"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159\/000513748"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3468(96)90338-3"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/uog.4051"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5167"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2018.08.022"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1159\/000295262"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7577"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000551305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T16:00:46Z","timestamp":1776268846000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000551305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,27]]},"references-count":21,"URL":"https:\/\/doi.org\/10.1159\/000551305","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"value":"1015-3837","type":"print"},{"value":"1421-9964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,27]]}}}